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Taurine Transporter Gene Expression in Mononuclear Blood Cells of Type 1 Diabetes Patients
المؤلفون المشاركون
Zinellu, Angelo
Anichini, Roberto
Franconi, Flavia
Campesi, Ilaria
Napoli, Zaleida
Seghieri, Giuseppe
Bianchi, Loria
Occhioni, Stefano
De Bellis, Alessandra
Carru, Ciriaco
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-03
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Taurine transporter gene expression (RNA-TauT) has a role in retinal cell function and is modulated in vitro and in vivo by hyperglycemia and/or oxidative stress.
This study was aimed at testing whether RNA-TauT gene expression is modified in blood mononuclear peripheral cells (MPCs) of type 1 diabetic patients, is related to plasma markers of oxidative stress or endothelial dysfunction, or, finally, is related to presence of retinopathy.
Methods.
RNA-TauT was measured in MPCs by real-time PCR-analysis in 35 type 1 diabetic patients and in 33 age- and sex-matched controls, additionally measuring plasma and cell taurine and markers of oxidative stress and endothelial dysfunction.
Results.
RNA-TauT, expressed as 2 - Δ Δ C t , was significantly higher in MPCs of type 1 diabetic patients than in controls [median (interquartile range): 1.32(0.31) versus 1.00(0.15); P = 0.01 ].
In diabetic patients RNA-TauT was related to HbA1c ( r = 0.42 ; P = 0.01 ) and inversely to plasma homocysteine ( r = - 0.39 ; P = 0.02 ) being additionally significantly higher in MPCs of patients without retinopathy [( n = 22 ); 1.36(0.34)] compared to those with retinopathy [( n = 13 ); 1.16(0.20)], independently from HbA1c or diabetes duration.
Conclusions.
RNA-TauT gene expression is significantly upregulated in MPCs of type 1 diabetes patients and is related to HbA1c levels and inversely to plasma homocysteine.
Finally, in diabetes patients, RNA-TauT upregulation seems to be blunted in patients with retinopathy independently of their metabolic control or longer diabetes duration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Napoli, Zaleida& Seghieri, Giuseppe& Bianchi, Loria& Anichini, Roberto& De Bellis, Alessandra& Campesi, Ilaria…[et al.]. 2016. Taurine Transporter Gene Expression in Mononuclear Blood Cells of Type 1 Diabetes Patients. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108236
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Napoli, Zaleida…[et al.]. Taurine Transporter Gene Expression in Mononuclear Blood Cells of Type 1 Diabetes Patients. Journal of Diabetes Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1108236
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Napoli, Zaleida& Seghieri, Giuseppe& Bianchi, Loria& Anichini, Roberto& De Bellis, Alessandra& Campesi, Ilaria…[et al.]. Taurine Transporter Gene Expression in Mononuclear Blood Cells of Type 1 Diabetes Patients. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108236
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108236
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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