Taurine Transporter Gene Expression in Mononuclear Blood Cells of Type 1 Diabetes Patients
Joint Authors
Zinellu, Angelo
Anichini, Roberto
Franconi, Flavia
Campesi, Ilaria
Napoli, Zaleida
Seghieri, Giuseppe
Bianchi, Loria
Occhioni, Stefano
De Bellis, Alessandra
Carru, Ciriaco
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Taurine transporter gene expression (RNA-TauT) has a role in retinal cell function and is modulated in vitro and in vivo by hyperglycemia and/or oxidative stress.
This study was aimed at testing whether RNA-TauT gene expression is modified in blood mononuclear peripheral cells (MPCs) of type 1 diabetic patients, is related to plasma markers of oxidative stress or endothelial dysfunction, or, finally, is related to presence of retinopathy.
Methods.
RNA-TauT was measured in MPCs by real-time PCR-analysis in 35 type 1 diabetic patients and in 33 age- and sex-matched controls, additionally measuring plasma and cell taurine and markers of oxidative stress and endothelial dysfunction.
Results.
RNA-TauT, expressed as 2 - Δ Δ C t , was significantly higher in MPCs of type 1 diabetic patients than in controls [median (interquartile range): 1.32(0.31) versus 1.00(0.15); P = 0.01 ].
In diabetic patients RNA-TauT was related to HbA1c ( r = 0.42 ; P = 0.01 ) and inversely to plasma homocysteine ( r = - 0.39 ; P = 0.02 ) being additionally significantly higher in MPCs of patients without retinopathy [( n = 22 ); 1.36(0.34)] compared to those with retinopathy [( n = 13 ); 1.16(0.20)], independently from HbA1c or diabetes duration.
Conclusions.
RNA-TauT gene expression is significantly upregulated in MPCs of type 1 diabetes patients and is related to HbA1c levels and inversely to plasma homocysteine.
Finally, in diabetes patients, RNA-TauT upregulation seems to be blunted in patients with retinopathy independently of their metabolic control or longer diabetes duration.
American Psychological Association (APA)
Napoli, Zaleida& Seghieri, Giuseppe& Bianchi, Loria& Anichini, Roberto& De Bellis, Alessandra& Campesi, Ilaria…[et al.]. 2016. Taurine Transporter Gene Expression in Mononuclear Blood Cells of Type 1 Diabetes Patients. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108236
Modern Language Association (MLA)
Napoli, Zaleida…[et al.]. Taurine Transporter Gene Expression in Mononuclear Blood Cells of Type 1 Diabetes Patients. Journal of Diabetes Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1108236
American Medical Association (AMA)
Napoli, Zaleida& Seghieri, Giuseppe& Bianchi, Loria& Anichini, Roberto& De Bellis, Alessandra& Campesi, Ilaria…[et al.]. Taurine Transporter Gene Expression in Mononuclear Blood Cells of Type 1 Diabetes Patients. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108236
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108236