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Naringenin Ameliorated Kidney Injury through Let-7aTGFBR1 Signaling in Diabetic Nephropathy
المؤلفون المشاركون
Yan, Ning
Wen, Li
Peng, Rui
Li, Hongmei
Liu, Handeng
Peng, Huimin
Sun, Yan
Wu, Tianhui
Chen, Lei
Duan, Qingrui
Sun, Yixuan
Zhou, Qin
Wei, Lijiang
Zhang, Zheng
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-30
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus (DM).
However, the exact mechanism is not clearly understood.
In this study, our results showed that 24 h urinary protein, kidney index, and glomerular area were decreased, while creatinine clearance ratio was increased in DN rats when the rats were treated with NAR 50 mg/d for 6 weeks.
Mesangial cell (MMCs) proliferation was inhibited in the NAR group by 3,(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), and the cell cycle analysis showed that cells stayed in G2 phase in NAR group.
And NAR treatment attenuated the deposition of ECM in DN rats and MMCs.
Moreover, our data showed that let-7a was downexpressed in both DN rats and MMCs under high glucose condition.
Surprisingly, NAR affected the expressions of Col4 and FN through upregulating let-7a in MMCs.
In addition, we found that let-7a negatively regulated the expression of transforming growth factor-β1 receptor 1 (TGFBR1), and TGFBR1 was required for the let-7a-mediated downregulation of TGF-β1/smad signaling.
Interestingly, NAR inhibited TGF-β1/smads signaling activation by upregulating let-7a.
Therefore, our findings indicated that NAR ameliorated kidney injury by regulating let-7a/TGFBR1 signaling.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yan, Ning& Wen, Li& Peng, Rui& Li, Hongmei& Liu, Handeng& Peng, Huimin…[et al.]. 2016. Naringenin Ameliorated Kidney Injury through Let-7aTGFBR1 Signaling in Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1108298
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yan, Ning…[et al.]. Naringenin Ameliorated Kidney Injury through Let-7aTGFBR1 Signaling in Diabetic Nephropathy. Journal of Diabetes Research No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1108298
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yan, Ning& Wen, Li& Peng, Rui& Li, Hongmei& Liu, Handeng& Peng, Huimin…[et al.]. Naringenin Ameliorated Kidney Injury through Let-7aTGFBR1 Signaling in Diabetic Nephropathy. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1108298
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108298
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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