Naringenin Ameliorated Kidney Injury through Let-7aTGFBR1 Signaling in Diabetic Nephropathy
Joint Authors
Yan, Ning
Wen, Li
Peng, Rui
Li, Hongmei
Liu, Handeng
Peng, Huimin
Sun, Yan
Wu, Tianhui
Chen, Lei
Duan, Qingrui
Sun, Yixuan
Zhou, Qin
Wei, Lijiang
Zhang, Zheng
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-30
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus (DM).
However, the exact mechanism is not clearly understood.
In this study, our results showed that 24 h urinary protein, kidney index, and glomerular area were decreased, while creatinine clearance ratio was increased in DN rats when the rats were treated with NAR 50 mg/d for 6 weeks.
Mesangial cell (MMCs) proliferation was inhibited in the NAR group by 3,(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), and the cell cycle analysis showed that cells stayed in G2 phase in NAR group.
And NAR treatment attenuated the deposition of ECM in DN rats and MMCs.
Moreover, our data showed that let-7a was downexpressed in both DN rats and MMCs under high glucose condition.
Surprisingly, NAR affected the expressions of Col4 and FN through upregulating let-7a in MMCs.
In addition, we found that let-7a negatively regulated the expression of transforming growth factor-β1 receptor 1 (TGFBR1), and TGFBR1 was required for the let-7a-mediated downregulation of TGF-β1/smad signaling.
Interestingly, NAR inhibited TGF-β1/smads signaling activation by upregulating let-7a.
Therefore, our findings indicated that NAR ameliorated kidney injury by regulating let-7a/TGFBR1 signaling.
American Psychological Association (APA)
Yan, Ning& Wen, Li& Peng, Rui& Li, Hongmei& Liu, Handeng& Peng, Huimin…[et al.]. 2016. Naringenin Ameliorated Kidney Injury through Let-7aTGFBR1 Signaling in Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1108298
Modern Language Association (MLA)
Yan, Ning…[et al.]. Naringenin Ameliorated Kidney Injury through Let-7aTGFBR1 Signaling in Diabetic Nephropathy. Journal of Diabetes Research No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1108298
American Medical Association (AMA)
Yan, Ning& Wen, Li& Peng, Rui& Li, Hongmei& Liu, Handeng& Peng, Huimin…[et al.]. Naringenin Ameliorated Kidney Injury through Let-7aTGFBR1 Signaling in Diabetic Nephropathy. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1108298
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108298