Polymorphism rs3828903 within MICB Is Associated with Susceptibility to Systemic Lupus Erythematosus in a Northern Han Chinese Population
المؤلفون المشاركون
Zhou, Xu-jie
Cheng, Fa-juan
Zhao, Ming-hui
Zhang, Hong
Zhang, Yue-miao
Hou, Ping
Qi, Yuan-yuan
المصدر
Journal of Immunology Research
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-28
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objectives.
The variant rs3828903 within MICB, a nonclassical MHC class I chain-related gene, was detected to contribute to systemic lupus erythematosus (SLE) in a Caucasian population.
This study aimed to investigate the association in a northern Han Chinese population.
Methods.
We recruited 1077 SLE patients and 793 controls for analysis.
rs3828903 was genotyped by TaqMan allele discrimination assay.
Using the public databases, its functional annotations and gene differential expression analysis of MICB were evaluated.
Results.
Significant association between the allele G of rs3828903 and risk susceptibility to SLE was observed after adjusting for sex and age ( P = 1.87 × 10 - 2 ).
In silico analyses predicted a higher affinity to transcription factors for allele G (risk) and cis-expression quantitative trait loci (cis-eQTL) effects of rs3828903 in multiple tissues ( P ranging from 2.79 × 10 - 6 to 6.27 × 10 - 38 ).
Furthermore, higher mRNA expressions of MICB were observed in B cells, monocytes, and renal biopsies from SLE patients compared to controls.
Conclusion.
An association between rs3828903 and susceptibility to SLE has been detected in a Chinese population.
This together with the functional annotations of rs3828903 converts MICB into a main candidate in the pathogenesis of SLE.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Yue-miao& Zhou, Xu-jie& Cheng, Fa-juan& Qi, Yuan-yuan& Hou, Ping& Zhao, Ming-hui…[et al.]. 2016. Polymorphism rs3828903 within MICB Is Associated with Susceptibility to Systemic Lupus Erythematosus in a Northern Han Chinese Population. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1108706
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Yue-miao…[et al.]. Polymorphism rs3828903 within MICB Is Associated with Susceptibility to Systemic Lupus Erythematosus in a Northern Han Chinese Population. Journal of Immunology Research No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1108706
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Yue-miao& Zhou, Xu-jie& Cheng, Fa-juan& Qi, Yuan-yuan& Hou, Ping& Zhao, Ming-hui…[et al.]. Polymorphism rs3828903 within MICB Is Associated with Susceptibility to Systemic Lupus Erythematosus in a Northern Han Chinese Population. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1108706
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108706
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر