Polymorphism rs3828903 within MICB Is Associated with Susceptibility to Systemic Lupus Erythematosus in a Northern Han Chinese Population
Joint Authors
Zhou, Xu-jie
Cheng, Fa-juan
Zhao, Ming-hui
Zhang, Hong
Zhang, Yue-miao
Hou, Ping
Qi, Yuan-yuan
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
The variant rs3828903 within MICB, a nonclassical MHC class I chain-related gene, was detected to contribute to systemic lupus erythematosus (SLE) in a Caucasian population.
This study aimed to investigate the association in a northern Han Chinese population.
Methods.
We recruited 1077 SLE patients and 793 controls for analysis.
rs3828903 was genotyped by TaqMan allele discrimination assay.
Using the public databases, its functional annotations and gene differential expression analysis of MICB were evaluated.
Results.
Significant association between the allele G of rs3828903 and risk susceptibility to SLE was observed after adjusting for sex and age ( P = 1.87 × 10 - 2 ).
In silico analyses predicted a higher affinity to transcription factors for allele G (risk) and cis-expression quantitative trait loci (cis-eQTL) effects of rs3828903 in multiple tissues ( P ranging from 2.79 × 10 - 6 to 6.27 × 10 - 38 ).
Furthermore, higher mRNA expressions of MICB were observed in B cells, monocytes, and renal biopsies from SLE patients compared to controls.
Conclusion.
An association between rs3828903 and susceptibility to SLE has been detected in a Chinese population.
This together with the functional annotations of rs3828903 converts MICB into a main candidate in the pathogenesis of SLE.
American Psychological Association (APA)
Zhang, Yue-miao& Zhou, Xu-jie& Cheng, Fa-juan& Qi, Yuan-yuan& Hou, Ping& Zhao, Ming-hui…[et al.]. 2016. Polymorphism rs3828903 within MICB Is Associated with Susceptibility to Systemic Lupus Erythematosus in a Northern Han Chinese Population. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1108706
Modern Language Association (MLA)
Zhang, Yue-miao…[et al.]. Polymorphism rs3828903 within MICB Is Associated with Susceptibility to Systemic Lupus Erythematosus in a Northern Han Chinese Population. Journal of Immunology Research No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1108706
American Medical Association (AMA)
Zhang, Yue-miao& Zhou, Xu-jie& Cheng, Fa-juan& Qi, Yuan-yuan& Hou, Ping& Zhao, Ming-hui…[et al.]. Polymorphism rs3828903 within MICB Is Associated with Susceptibility to Systemic Lupus Erythematosus in a Northern Han Chinese Population. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1108706
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108706