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Plasma IL-6IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumocystis Pneumonia
المؤلفون المشاركون
Sun, Jia
Su, Junwei
Xie, Yirui
Yin, Michael T.
Huang, Ying
Xu, Lijun
Zhou, Qihui
Zhu, Biao
المصدر
Journal of Immunology Research
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-07
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
To identify blood biomarkers to predict severity and mortality in AIDS PCP patients.
Methods.
Biomarkers including clinical parameters and plasma inflammatory cytokines were assessed in 32 HIV-infected patients with Pneumocystis pneumonia (PCP) at time of admission.
Predictive value of the biomarkers for clinical severity and in-hospital mortality was evaluated by corresponding ROC curve.
Results.
Levels of CRP, WBC, LDH, HBDH, and Ferritin were significantly higher in the severe and nonsurvivor AIDS PCP patients.
These important biochemical indicators have inverse correlation with oxygenation index, especially levels of LDH ( P = 0.008 , R 2 = 0.258 ), HBDH ( P = 0.001 , R 2 = 0.335 ), and Ferritin ( P = 0.005 , R 2 = 0.237 ).
Plasma IL-8 and IL-6 levels were significantly higher in patients with PaO2/FiO2 ≤ 200 mmHg and nonsurvivors than in those with PaO2/FiO2 > 200 mmHg and survivors.
Severe and nonsurvival groups showed higher ratio of mean IL-6/IL-10 level (1.78 ± 1.56, P < 0.0 01 ; 1.11 ± 0.72, P = 0.043 ), larger AUC (95% CI 0.781–1.000, P < 0.00 1 ; 95% CI 0.592–0.917, P = 0.043 ), and more significantly inverse correlation with the oxygenation index.
Conclusion.
Plasma IL-8, LDH, and HBDH levels and IL-6/IL-10 ratio could be helpful for early evaluation of the severity and predicting fatal outcomes in AIDS PCP patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Jia& Su, Junwei& Xie, Yirui& Yin, Michael T.& Huang, Ying& Xu, Lijun…[et al.]. 2016. Plasma IL-6IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumocystis Pneumonia. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108716
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Jia…[et al.]. Plasma IL-6IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumocystis Pneumonia. Journal of Immunology Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108716
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Jia& Su, Junwei& Xie, Yirui& Yin, Michael T.& Huang, Ying& Xu, Lijun…[et al.]. Plasma IL-6IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumocystis Pneumonia. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108716
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108716
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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