Plasma IL-6IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumocystis Pneumonia
Joint Authors
Sun, Jia
Su, Junwei
Xie, Yirui
Yin, Michael T.
Huang, Ying
Xu, Lijun
Zhou, Qihui
Zhu, Biao
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
To identify blood biomarkers to predict severity and mortality in AIDS PCP patients.
Methods.
Biomarkers including clinical parameters and plasma inflammatory cytokines were assessed in 32 HIV-infected patients with Pneumocystis pneumonia (PCP) at time of admission.
Predictive value of the biomarkers for clinical severity and in-hospital mortality was evaluated by corresponding ROC curve.
Results.
Levels of CRP, WBC, LDH, HBDH, and Ferritin were significantly higher in the severe and nonsurvivor AIDS PCP patients.
These important biochemical indicators have inverse correlation with oxygenation index, especially levels of LDH ( P = 0.008 , R 2 = 0.258 ), HBDH ( P = 0.001 , R 2 = 0.335 ), and Ferritin ( P = 0.005 , R 2 = 0.237 ).
Plasma IL-8 and IL-6 levels were significantly higher in patients with PaO2/FiO2 ≤ 200 mmHg and nonsurvivors than in those with PaO2/FiO2 > 200 mmHg and survivors.
Severe and nonsurvival groups showed higher ratio of mean IL-6/IL-10 level (1.78 ± 1.56, P < 0.0 01 ; 1.11 ± 0.72, P = 0.043 ), larger AUC (95% CI 0.781–1.000, P < 0.00 1 ; 95% CI 0.592–0.917, P = 0.043 ), and more significantly inverse correlation with the oxygenation index.
Conclusion.
Plasma IL-8, LDH, and HBDH levels and IL-6/IL-10 ratio could be helpful for early evaluation of the severity and predicting fatal outcomes in AIDS PCP patients.
American Psychological Association (APA)
Sun, Jia& Su, Junwei& Xie, Yirui& Yin, Michael T.& Huang, Ying& Xu, Lijun…[et al.]. 2016. Plasma IL-6IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumocystis Pneumonia. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108716
Modern Language Association (MLA)
Sun, Jia…[et al.]. Plasma IL-6IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumocystis Pneumonia. Journal of Immunology Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108716
American Medical Association (AMA)
Sun, Jia& Su, Junwei& Xie, Yirui& Yin, Michael T.& Huang, Ying& Xu, Lijun…[et al.]. Plasma IL-6IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumocystis Pneumonia. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108716
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108716