Unraveling the Effect of Immunogenicity on the PKPD, Efficacy, and Safety of Therapeutic Proteins
المؤلفون المشاركون
Smith, Alison
Manoli, Hugh
Jaw, Stacey
Frutoz, Kimberley
Epstein, Alan L.
Khawli, Leslie A.
Theil, Frank-Peter
المصدر
Journal of Immunology Research
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Biologics have emerged as a powerful and diverse class of molecular and cell-based therapies that are capable of replacing enzymes, editing genomes, targeting tumors, and more.
As this complex array of tools arises a distinct set of challenges is rarely encountered in the development of small molecule therapies.
Biotherapeutics tend to be big, bulky, polar molecules comprised of protein and/or nucleic acids.
Compared to their small molecule counterparts, they are fragile, labile, and heterogeneous.
Their biodistribution is often limited by hydrophobic barriers which often restrict their administration to either intravenous or subcutaneous entry routes.
Additionally, their potential for immunogenicity has proven to be a challenge to developing safe and reliably efficacious drugs.
Our discussion will emphasize immunogenicity in the context of therapeutic proteins, a well-known class of biologics.
We set out to describe what is known and unknown about the mechanisms underlying the interplay between antigenicity and immune response and their effect on the safety, efficacy, pharmacokinetics, and pharmacodynamics of these therapeutic agents.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Smith, Alison& Manoli, Hugh& Jaw, Stacey& Frutoz, Kimberley& Epstein, Alan L.& Khawli, Leslie A.…[et al.]. 2016. Unraveling the Effect of Immunogenicity on the PKPD, Efficacy, and Safety of Therapeutic Proteins. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108732
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Smith, Alison…[et al.]. Unraveling the Effect of Immunogenicity on the PKPD, Efficacy, and Safety of Therapeutic Proteins. Journal of Immunology Research No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1108732
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Smith, Alison& Manoli, Hugh& Jaw, Stacey& Frutoz, Kimberley& Epstein, Alan L.& Khawli, Leslie A.…[et al.]. Unraveling the Effect of Immunogenicity on the PKPD, Efficacy, and Safety of Therapeutic Proteins. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108732
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108732
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر