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Unraveling the Effect of Immunogenicity on the PKPD, Efficacy, and Safety of Therapeutic Proteins
Joint Authors
Smith, Alison
Manoli, Hugh
Jaw, Stacey
Frutoz, Kimberley
Epstein, Alan L.
Khawli, Leslie A.
Theil, Frank-Peter
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Biologics have emerged as a powerful and diverse class of molecular and cell-based therapies that are capable of replacing enzymes, editing genomes, targeting tumors, and more.
As this complex array of tools arises a distinct set of challenges is rarely encountered in the development of small molecule therapies.
Biotherapeutics tend to be big, bulky, polar molecules comprised of protein and/or nucleic acids.
Compared to their small molecule counterparts, they are fragile, labile, and heterogeneous.
Their biodistribution is often limited by hydrophobic barriers which often restrict their administration to either intravenous or subcutaneous entry routes.
Additionally, their potential for immunogenicity has proven to be a challenge to developing safe and reliably efficacious drugs.
Our discussion will emphasize immunogenicity in the context of therapeutic proteins, a well-known class of biologics.
We set out to describe what is known and unknown about the mechanisms underlying the interplay between antigenicity and immune response and their effect on the safety, efficacy, pharmacokinetics, and pharmacodynamics of these therapeutic agents.
American Psychological Association (APA)
Smith, Alison& Manoli, Hugh& Jaw, Stacey& Frutoz, Kimberley& Epstein, Alan L.& Khawli, Leslie A.…[et al.]. 2016. Unraveling the Effect of Immunogenicity on the PKPD, Efficacy, and Safety of Therapeutic Proteins. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108732
Modern Language Association (MLA)
Smith, Alison…[et al.]. Unraveling the Effect of Immunogenicity on the PKPD, Efficacy, and Safety of Therapeutic Proteins. Journal of Immunology Research No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1108732
American Medical Association (AMA)
Smith, Alison& Manoli, Hugh& Jaw, Stacey& Frutoz, Kimberley& Epstein, Alan L.& Khawli, Leslie A.…[et al.]. Unraveling the Effect of Immunogenicity on the PKPD, Efficacy, and Safety of Therapeutic Proteins. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108732
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108732