Crucial Contributions by T Lymphocytes (Effector, Regulatory, and Checkpoint Inhibitor) and Cytokines (TH1, TH2, and TH17) to a Pathological Complete Response Induced by Neoadjuvant Chemotherapy in Women with Breast Cancer
المؤلفون المشاركون
Kaewkangsadan, Viriya
Verma, Chandan
Eremin, Jennifer M.
Cowley, Gerard
Ilyas, Mohammed
Eremin, Oleg
المصدر
Journal of Immunology Research
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-25، 25ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-29
دولة النشر
مصر
عدد الصفحات
25
التخصصات الرئيسية
الملخص EN
The tumour microenvironment consists of malignant cells, stroma, and immune cells.
Prominent tumour-infiltrating lymphocytes (TILs) in breast cancer are associated with a good prognosis and are predictors of a pathological complete response (pCR) with neoadjuvant chemotherapy (NAC).
The contribution of different T effector/regulatory cells and cytokines to tumour cell death with NAC requires further characterisation and was investigated in this study.
Breast tumours from 33 women with large and locally advanced breast cancers undergoing NAC were immunohistochemically (intratumoural, stromal) assessed for T cell subsets and cytokine expression using labelled antibodies, employing established semiquantitative methods.
Prominent levels of TILs and CD4+, CD8+, and CTLA-4+ (stromal) T cells and CD8+ : FOXP3+ ratios were associated with a significant pCR; no association was seen with FOXP3+, CTLA-4+ (intratumoural), and PD-1+ T cells.
NAC significantly reduced CD4+, FOXP3+, CTLA-4+ (stromal) (concurrently blood FOXP3+, CTLA-4+ Tregs), and PD-1+ T cells; no reduction was seen with CD8+ and CTLA-4+ (intratumoural) T cells.
High post-NAC tumour levels of FOXP3+ T cells, IL-10, and IL-17 were associated with a failed pCR.
Our study has characterised further the contribution of T effector/regulatory cells and cytokines to tumour cell death with NAC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kaewkangsadan, Viriya& Verma, Chandan& Eremin, Jennifer M.& Cowley, Gerard& Ilyas, Mohammed& Eremin, Oleg. 2016. Crucial Contributions by T Lymphocytes (Effector, Regulatory, and Checkpoint Inhibitor) and Cytokines (TH1, TH2, and TH17) to a Pathological Complete Response Induced by Neoadjuvant Chemotherapy in Women with Breast Cancer. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-25.
https://search.emarefa.net/detail/BIM-1108797
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kaewkangsadan, Viriya…[et al.]. Crucial Contributions by T Lymphocytes (Effector, Regulatory, and Checkpoint Inhibitor) and Cytokines (TH1, TH2, and TH17) to a Pathological Complete Response Induced by Neoadjuvant Chemotherapy in Women with Breast Cancer. Journal of Immunology Research No. 2016 (2016), pp.1-25.
https://search.emarefa.net/detail/BIM-1108797
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kaewkangsadan, Viriya& Verma, Chandan& Eremin, Jennifer M.& Cowley, Gerard& Ilyas, Mohammed& Eremin, Oleg. Crucial Contributions by T Lymphocytes (Effector, Regulatory, and Checkpoint Inhibitor) and Cytokines (TH1, TH2, and TH17) to a Pathological Complete Response Induced by Neoadjuvant Chemotherapy in Women with Breast Cancer. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-25.
https://search.emarefa.net/detail/BIM-1108797
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108797
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر