Crucial Contributions by T Lymphocytes (Effector, Regulatory, and Checkpoint Inhibitor) and Cytokines (TH1, TH2, and TH17) to a Pathological Complete Response Induced by Neoadjuvant Chemotherapy in Women with Breast Cancer
Joint Authors
Kaewkangsadan, Viriya
Verma, Chandan
Eremin, Jennifer M.
Cowley, Gerard
Ilyas, Mohammed
Eremin, Oleg
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-25, 25 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-29
Country of Publication
Egypt
No. of Pages
25
Main Subjects
Abstract EN
The tumour microenvironment consists of malignant cells, stroma, and immune cells.
Prominent tumour-infiltrating lymphocytes (TILs) in breast cancer are associated with a good prognosis and are predictors of a pathological complete response (pCR) with neoadjuvant chemotherapy (NAC).
The contribution of different T effector/regulatory cells and cytokines to tumour cell death with NAC requires further characterisation and was investigated in this study.
Breast tumours from 33 women with large and locally advanced breast cancers undergoing NAC were immunohistochemically (intratumoural, stromal) assessed for T cell subsets and cytokine expression using labelled antibodies, employing established semiquantitative methods.
Prominent levels of TILs and CD4+, CD8+, and CTLA-4+ (stromal) T cells and CD8+ : FOXP3+ ratios were associated with a significant pCR; no association was seen with FOXP3+, CTLA-4+ (intratumoural), and PD-1+ T cells.
NAC significantly reduced CD4+, FOXP3+, CTLA-4+ (stromal) (concurrently blood FOXP3+, CTLA-4+ Tregs), and PD-1+ T cells; no reduction was seen with CD8+ and CTLA-4+ (intratumoural) T cells.
High post-NAC tumour levels of FOXP3+ T cells, IL-10, and IL-17 were associated with a failed pCR.
Our study has characterised further the contribution of T effector/regulatory cells and cytokines to tumour cell death with NAC.
American Psychological Association (APA)
Kaewkangsadan, Viriya& Verma, Chandan& Eremin, Jennifer M.& Cowley, Gerard& Ilyas, Mohammed& Eremin, Oleg. 2016. Crucial Contributions by T Lymphocytes (Effector, Regulatory, and Checkpoint Inhibitor) and Cytokines (TH1, TH2, and TH17) to a Pathological Complete Response Induced by Neoadjuvant Chemotherapy in Women with Breast Cancer. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-25.
https://search.emarefa.net/detail/BIM-1108797
Modern Language Association (MLA)
Kaewkangsadan, Viriya…[et al.]. Crucial Contributions by T Lymphocytes (Effector, Regulatory, and Checkpoint Inhibitor) and Cytokines (TH1, TH2, and TH17) to a Pathological Complete Response Induced by Neoadjuvant Chemotherapy in Women with Breast Cancer. Journal of Immunology Research No. 2016 (2016), pp.1-25.
https://search.emarefa.net/detail/BIM-1108797
American Medical Association (AMA)
Kaewkangsadan, Viriya& Verma, Chandan& Eremin, Jennifer M.& Cowley, Gerard& Ilyas, Mohammed& Eremin, Oleg. Crucial Contributions by T Lymphocytes (Effector, Regulatory, and Checkpoint Inhibitor) and Cytokines (TH1, TH2, and TH17) to a Pathological Complete Response Induced by Neoadjuvant Chemotherapy in Women with Breast Cancer. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-25.
https://search.emarefa.net/detail/BIM-1108797
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108797