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Immunomodulatory Effects of 1,25-Dihydroxyvitamin D3 on Dendritic Cells Promote Induction of T Cell Hyporesponsiveness to Myelin-Derived Antigens
المؤلفون المشاركون
Cras, Patrick
Lee, Wai-Ping
Goossens, Herman
Willekens, Barbara
Martínez-Cáceres, Eva
Cools, Nathalie
Berneman, Zwi N.
المصدر
Journal of Immunology Research
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-14
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
While emerging evidence indicates that dendritic cells (DC) play a central role in the pathogenesis of multiple sclerosis (MS), their modulation with immunoregulatory agents provides prospect as disease-modifying therapy.
Our observations reveal that 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) treatment of monocyte-derived DC results in a semimature phenotype and anti-inflammatory cytokine profile as compared to conventional DC, in both healthy controls and MS patients.
Importantly, 1,25(OH)2D3-treated DC induce T cell hyporesponsiveness, as demonstrated in an allogeneic mixed leukocyte reaction.
Next, following a freeze-thaw cycle, 1,25(OH)2D3-treated immature DC could be recovered with a 78% yield and 75% viability.
Cryopreservation did not affect the expression of membrane markers by 1,25(OH)2D3-treated DC nor their capacity to induce T cell hyporesponsiveness.
In addition, the T cell hyporesponsiveness induced by 1,25(OH)2D3-treated DC is antigen-specific and robust since T cells retain their capacity to respond to an unrelated antigen and do not reactivate upon rechallenge with fully mature conventional DC, respectively.
These observations underline the clinical potential of tolerogenic DC (tolDC) to correct the immunological imbalance in MS.
Furthermore, the feasibility to cryopreserve highly potent tolDC will, ultimately, contribute to the large-scale production and the widely applicable use of tolDC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Wai-Ping& Willekens, Barbara& Cras, Patrick& Goossens, Herman& Martínez-Cáceres, Eva& Berneman, Zwi N.…[et al.]. 2016. Immunomodulatory Effects of 1,25-Dihydroxyvitamin D3 on Dendritic Cells Promote Induction of T Cell Hyporesponsiveness to Myelin-Derived Antigens. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1108821
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Wai-Ping…[et al.]. Immunomodulatory Effects of 1,25-Dihydroxyvitamin D3 on Dendritic Cells Promote Induction of T Cell Hyporesponsiveness to Myelin-Derived Antigens. Journal of Immunology Research No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1108821
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Wai-Ping& Willekens, Barbara& Cras, Patrick& Goossens, Herman& Martínez-Cáceres, Eva& Berneman, Zwi N.…[et al.]. Immunomodulatory Effects of 1,25-Dihydroxyvitamin D3 on Dendritic Cells Promote Induction of T Cell Hyporesponsiveness to Myelin-Derived Antigens. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1108821
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108821
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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