Monocyte-Derived Macrophages Are Impaired in Myelodysplastic Syndrome
المؤلفون المشاركون
Shao, Zonghong
Han, Yu
Wang, Huaquan
المصدر
Journal of Immunology Research
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-15
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
The myelodysplastic syndrome (MDS) comprises a group of clonal hematopoietic stem cell diseases characterized by cytopenia, dysplasia in one or more of the major myeloid lineages, ineffective hematopoiesis, and increased risk of development of acute myeloid leukemia (AML).
Macrophages are innate immune cells that ingest and degrade abnormal cells, debris, and foreign material and orchestrate inflammatory processes.
We analyzed the role of macrophages from MDS patients in vitro.
Methods.
Macrophages were induced from peripheral blood of patients with MDS via granulocyte macrophage colony-stimulating factor (GM-CSF).
Phagocytic capacity of macrophages was measured with carboxyfluorescein succinimidyl ester and fluorescent microspheres.
CD206 and signal regulatory protein alpha (SIRPα) on macrophages were detected by flow cytometry.
Inducible nitric oxide synthase (iNOS) was measured by ELISA method.
Results.
Compared with normal control group, the number of monocytes increased in MDS patients.
However, the monocytes showed impaired ability to induce macrophages and the number of macrophages induced from MDS samples was lower.
Further, we demonstrated that the ex vivo phagocytic function of macrophages from MDS patients was impaired and levels of reorganization receptors CD206 and SIRPα were lower.
Levels of iNOS secreted by macrophages in MDS were increased.
Conclusions.
Monocyte-derived macrophages are impaired in myelodysplastic syndromes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Han, Yu& Wang, Huaquan& Shao, Zonghong. 2016. Monocyte-Derived Macrophages Are Impaired in Myelodysplastic Syndrome. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108824
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Han, Yu…[et al.]. Monocyte-Derived Macrophages Are Impaired in Myelodysplastic Syndrome. Journal of Immunology Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1108824
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Han, Yu& Wang, Huaquan& Shao, Zonghong. Monocyte-Derived Macrophages Are Impaired in Myelodysplastic Syndrome. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108824
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108824
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر