Biological Character of RetroNectin Activated Cytokine-Induced Killer Cells
المؤلفون المشاركون
Song, Yong-ping
Han, Lu
Shang, Yi-Man
Gao, Quan-Li
المصدر
Journal of Immunology Research
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-28
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Adoptive cell therapy (ACT) using autologous cytokine-induced killer (CIK) cells is a promising treatment for metastatic carcinomas.
In this study, we investigated the impact of RetroNectin on the proliferation, phenotype alternation, cytokine secretion, and cytotoxic activity of CIK cells from pancreatic cancer patients.
Furthermore, we treated 13 patients with metastatic or locally advanced pancreatic cancer using autologous RetroNectin-activated CIK cells (R-CIK cells) alone or in combination with chemotherapy.
Compared with only CD3 activated CIK cells (OKT-CIK cells), R-CIK cells showed stronger and faster proliferative ability, with a lower ratio of spontaneous apoptosis.
Moreover, this ability continued after IL-2 was withdrawn from the culture system.
R-CIK cells could also secrete higher levels of IL-2 and lower levels of IL-4 and IL-5 versus OKT-CIK cells.
There was no difference between OKT-CIK and R-CIK cells in cytotoxic ability against lymphoma cell line K562.
In patients who received auto-R-CIK cell infusion therapy, the overall objective response rate was 23.1%.
Median survival time (mOS) after first R-CIK cell infusion was 10.57 months; the 1-year survival rate was 38.5%.
No serious toxicity was associated with R-CIK cell infusion.
In conclusion, RetroNectin may enhance antitumor activity of CIK cells: it is safe for use in treating pancreatic cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Han, Lu& Shang, Yi-Man& Song, Yong-ping& Gao, Quan-Li. 2016. Biological Character of RetroNectin Activated Cytokine-Induced Killer Cells. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108828
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Han, Lu…[et al.]. Biological Character of RetroNectin Activated Cytokine-Induced Killer Cells. Journal of Immunology Research No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1108828
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Han, Lu& Shang, Yi-Man& Song, Yong-ping& Gao, Quan-Li. Biological Character of RetroNectin Activated Cytokine-Induced Killer Cells. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108828
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108828
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر