Biological Character of RetroNectin Activated Cytokine-Induced Killer Cells

Joint Authors

Song, Yong-ping
Han, Lu
Shang, Yi-Man
Gao, Quan-Li

Source

Journal of Immunology Research

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-06-28

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Biology

Abstract EN

Adoptive cell therapy (ACT) using autologous cytokine-induced killer (CIK) cells is a promising treatment for metastatic carcinomas.

In this study, we investigated the impact of RetroNectin on the proliferation, phenotype alternation, cytokine secretion, and cytotoxic activity of CIK cells from pancreatic cancer patients.

Furthermore, we treated 13 patients with metastatic or locally advanced pancreatic cancer using autologous RetroNectin-activated CIK cells (R-CIK cells) alone or in combination with chemotherapy.

Compared with only CD3 activated CIK cells (OKT-CIK cells), R-CIK cells showed stronger and faster proliferative ability, with a lower ratio of spontaneous apoptosis.

Moreover, this ability continued after IL-2 was withdrawn from the culture system.

R-CIK cells could also secrete higher levels of IL-2 and lower levels of IL-4 and IL-5 versus OKT-CIK cells.

There was no difference between OKT-CIK and R-CIK cells in cytotoxic ability against lymphoma cell line K562.

In patients who received auto-R-CIK cell infusion therapy, the overall objective response rate was 23.1%.

Median survival time (mOS) after first R-CIK cell infusion was 10.57 months; the 1-year survival rate was 38.5%.

No serious toxicity was associated with R-CIK cell infusion.

In conclusion, RetroNectin may enhance antitumor activity of CIK cells: it is safe for use in treating pancreatic cancer.

American Psychological Association (APA)

Han, Lu& Shang, Yi-Man& Song, Yong-ping& Gao, Quan-Li. 2016. Biological Character of RetroNectin Activated Cytokine-Induced Killer Cells. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108828

Modern Language Association (MLA)

Han, Lu…[et al.]. Biological Character of RetroNectin Activated Cytokine-Induced Killer Cells. Journal of Immunology Research No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1108828

American Medical Association (AMA)

Han, Lu& Shang, Yi-Man& Song, Yong-ping& Gao, Quan-Li. Biological Character of RetroNectin Activated Cytokine-Induced Killer Cells. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108828

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1108828