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Impact of Ivabradine on Inflammatory Markers in Chronic Heart Failure
المؤلفون المشاركون
Rohm, Ilonka
Kretzschmar, Daniel
Yilmaz, Atilla
Pistulli, Rudin
Schulze, P. Christian
Stumpf, Christian
Franz, Marcus
المصدر
Journal of Immunology Research
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-16
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Inflammation plays a crucial role in the progression of chronic heart failure (CHF).
Ivabradine is known to reduce the morbidity and mortality of patients with CHF under certain conditions.
Beyond the reduction of heart rate, only limited knowledge exists about potential anti-inflammatory effects of ivabradine that might contribute to its benefit in CHF.
Thus, the present study aimed to investigate the effect of ivabradine on systemic inflammation.
Methods.
In the present study, 33 patients with CHF due to dilated, ischemic, and hypertensive cardiomyopathy were treated with ivabradine according to the guidelines of the European Society of Cardiology (ESC).
A number of circulating dendritic cells as well as inflammatory mediators were investigated using FACS analysis and ELISA, respectively, before and during ivabradine therapy.
Results.
Treatment with ivabradine resulted in a significant improvement of CHF symptoms as well as an increase in left ventricular ejection fraction.
Moreover, ivabradine treatment led to a significant reduction of TNF-alpha (TNF-α) serum levels and a reconstitution of circulating dendritic cells which are known to be reduced in patients with CHF.
Conclusion.
We show that treatment with ivabradine in patients with CHF resulted in an improvement of HF symptoms and ejection fraction as well as a normalization of inflammatory mediators.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rohm, Ilonka& Kretzschmar, Daniel& Pistulli, Rudin& Franz, Marcus& Schulze, P. Christian& Stumpf, Christian…[et al.]. 2016. Impact of Ivabradine on Inflammatory Markers in Chronic Heart Failure. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108862
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rohm, Ilonka…[et al.]. Impact of Ivabradine on Inflammatory Markers in Chronic Heart Failure. Journal of Immunology Research No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1108862
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rohm, Ilonka& Kretzschmar, Daniel& Pistulli, Rudin& Franz, Marcus& Schulze, P. Christian& Stumpf, Christian…[et al.]. Impact of Ivabradine on Inflammatory Markers in Chronic Heart Failure. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108862
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108862
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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