Impact of Ivabradine on Inflammatory Markers in Chronic Heart Failure
Joint Authors
Rohm, Ilonka
Kretzschmar, Daniel
Yilmaz, Atilla
Pistulli, Rudin
Schulze, P. Christian
Stumpf, Christian
Franz, Marcus
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Inflammation plays a crucial role in the progression of chronic heart failure (CHF).
Ivabradine is known to reduce the morbidity and mortality of patients with CHF under certain conditions.
Beyond the reduction of heart rate, only limited knowledge exists about potential anti-inflammatory effects of ivabradine that might contribute to its benefit in CHF.
Thus, the present study aimed to investigate the effect of ivabradine on systemic inflammation.
Methods.
In the present study, 33 patients with CHF due to dilated, ischemic, and hypertensive cardiomyopathy were treated with ivabradine according to the guidelines of the European Society of Cardiology (ESC).
A number of circulating dendritic cells as well as inflammatory mediators were investigated using FACS analysis and ELISA, respectively, before and during ivabradine therapy.
Results.
Treatment with ivabradine resulted in a significant improvement of CHF symptoms as well as an increase in left ventricular ejection fraction.
Moreover, ivabradine treatment led to a significant reduction of TNF-alpha (TNF-α) serum levels and a reconstitution of circulating dendritic cells which are known to be reduced in patients with CHF.
Conclusion.
We show that treatment with ivabradine in patients with CHF resulted in an improvement of HF symptoms and ejection fraction as well as a normalization of inflammatory mediators.
American Psychological Association (APA)
Rohm, Ilonka& Kretzschmar, Daniel& Pistulli, Rudin& Franz, Marcus& Schulze, P. Christian& Stumpf, Christian…[et al.]. 2016. Impact of Ivabradine on Inflammatory Markers in Chronic Heart Failure. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108862
Modern Language Association (MLA)
Rohm, Ilonka…[et al.]. Impact of Ivabradine on Inflammatory Markers in Chronic Heart Failure. Journal of Immunology Research No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1108862
American Medical Association (AMA)
Rohm, Ilonka& Kretzschmar, Daniel& Pistulli, Rudin& Franz, Marcus& Schulze, P. Christian& Stumpf, Christian…[et al.]. Impact of Ivabradine on Inflammatory Markers in Chronic Heart Failure. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108862
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108862