Evaluation of PD-L1 Expression in Tumor Tissue of Patients with Lung Carcinoma and Correlation with Clinical and Demographic Data
المؤلفون المشاركون
de Souza Viana, Luciano
Dix Junqueira Pinto, Gustavo
Scapulatempo Neto, Cristovam
Vicente Serrano, Sérgio
المصدر
Journal of Immunology Research
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-22
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Lung cancer is the leading world cause of cancer-related death, in both genders, and smoking is the main etiological factor.
The discovery of immune checkpoints corroborates the hypothesis that ligands presented in tumors modulate the mechanisms of carcinogenesis and the immune activity of tumor microenvironment.
Among the most studied coregulatory molecules, PD-1 (programmed cell death 1) and its ligand PD-L1 (programmed cell death 1 ligand 1) are noteworthy.
The present study aims to enhance the understanding of the tumor microenvironment of lung cancer patients who underwent surgery, by means of analysis of PD-L1 expression in tumor cells and in intratumoral immune cells (IICs).
It was found that PD-L1 expression was more frequent in tumor cells than in IICs.
Collective analysis by Tissue Microarray Assay (TMA) for PD-L1 expression in tumor cells and IICs did not reproduce the findings for separate individual analysis of tumor tissues.
Patients with past history of smoking were more likely to express PD-L1 in tumor cells than those who never smoked.
Patients with past history of smoking were less likely to have PD-L1 positive IICs compared to those who had never smoked.
The immunohistochemical expression of PD-L1 in tumor cells and IICs did not correlate with survival.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dix Junqueira Pinto, Gustavo& de Souza Viana, Luciano& Scapulatempo Neto, Cristovam& Vicente Serrano, Sérgio. 2016. Evaluation of PD-L1 Expression in Tumor Tissue of Patients with Lung Carcinoma and Correlation with Clinical and Demographic Data. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108927
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dix Junqueira Pinto, Gustavo…[et al.]. Evaluation of PD-L1 Expression in Tumor Tissue of Patients with Lung Carcinoma and Correlation with Clinical and Demographic Data. Journal of Immunology Research No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1108927
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dix Junqueira Pinto, Gustavo& de Souza Viana, Luciano& Scapulatempo Neto, Cristovam& Vicente Serrano, Sérgio. Evaluation of PD-L1 Expression in Tumor Tissue of Patients with Lung Carcinoma and Correlation with Clinical and Demographic Data. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108927
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108927
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر