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Evaluation of PD-L1 Expression in Tumor Tissue of Patients with Lung Carcinoma and Correlation with Clinical and Demographic Data
Joint Authors
de Souza Viana, Luciano
Dix Junqueira Pinto, Gustavo
Scapulatempo Neto, Cristovam
Vicente Serrano, Sérgio
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Lung cancer is the leading world cause of cancer-related death, in both genders, and smoking is the main etiological factor.
The discovery of immune checkpoints corroborates the hypothesis that ligands presented in tumors modulate the mechanisms of carcinogenesis and the immune activity of tumor microenvironment.
Among the most studied coregulatory molecules, PD-1 (programmed cell death 1) and its ligand PD-L1 (programmed cell death 1 ligand 1) are noteworthy.
The present study aims to enhance the understanding of the tumor microenvironment of lung cancer patients who underwent surgery, by means of analysis of PD-L1 expression in tumor cells and in intratumoral immune cells (IICs).
It was found that PD-L1 expression was more frequent in tumor cells than in IICs.
Collective analysis by Tissue Microarray Assay (TMA) for PD-L1 expression in tumor cells and IICs did not reproduce the findings for separate individual analysis of tumor tissues.
Patients with past history of smoking were more likely to express PD-L1 in tumor cells than those who never smoked.
Patients with past history of smoking were less likely to have PD-L1 positive IICs compared to those who had never smoked.
The immunohistochemical expression of PD-L1 in tumor cells and IICs did not correlate with survival.
American Psychological Association (APA)
Dix Junqueira Pinto, Gustavo& de Souza Viana, Luciano& Scapulatempo Neto, Cristovam& Vicente Serrano, Sérgio. 2016. Evaluation of PD-L1 Expression in Tumor Tissue of Patients with Lung Carcinoma and Correlation with Clinical and Demographic Data. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108927
Modern Language Association (MLA)
Dix Junqueira Pinto, Gustavo…[et al.]. Evaluation of PD-L1 Expression in Tumor Tissue of Patients with Lung Carcinoma and Correlation with Clinical and Demographic Data. Journal of Immunology Research No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1108927
American Medical Association (AMA)
Dix Junqueira Pinto, Gustavo& de Souza Viana, Luciano& Scapulatempo Neto, Cristovam& Vicente Serrano, Sérgio. Evaluation of PD-L1 Expression in Tumor Tissue of Patients with Lung Carcinoma and Correlation with Clinical and Demographic Data. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108927
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108927