Normal Non-HDL Cholesterol, Low Total Cholesterol, and HDL Cholesterol Levels in Sickle Cell Disease Patients in the Steady State: A Case-Control Study of Tema Metropolis
المؤلفون المشاركون
Adu, Patrick
Ephraim, Richard K. D.
Ake, Edem
Agbodzakey, Hope
Adoba, Prince
Cudjoe, Obed
Agoni, Clement
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-18
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Abnormal lipid homeostasis in sickle cell disease (SCD) is characterized by defects in plasma and erythrocyte lipids and may increase the risk of cardiovascular disease.
This study assessed the lipid profile and non-HDL cholesterol level of SCD patients.
Methods.
A hospital-based cross-sectional study was conducted in 50 SCD patients, in the steady state, aged 8–28 years, attending the SCD clinic, and 50 healthy volunteers between the ages of 8–38 years.
Serum lipids were determined by enzymatic methods and non-HDL cholesterol calculated by this formula: non-HDL-C = TC-HDL-C.
Results.
Total cholesterol (TC) ( p = 0.001 ) and high-density lipoprotein cholesterol (HDL-C) ( p < 0.0001 ) were significantly decreased in cases compared to controls.
The levels of non-HDL-C, low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) were similar among the participants.
The levels of decrease in TC and HDL were associated with whether a patient was SCD-SS or SCD-SC.
Systolic blood pressure and diastolic blood pressure were each significantly associated with increased VLDL [SBP, p = 0.01 , OR: 0.74 (CI: 0.6–0.93); DBP, p = 0.023 , OR: 1.45 (CI: 1.05–2.0)].
Conclusion.
Dyslipidemia is common among participants in this study.
It was more pronounced in the SCD-SS than in SCD-SC.
This dyslipidemia was associated with high VLDL as well as increased SBP and DBP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ephraim, Richard K. D.& Adu, Patrick& Ake, Edem& Agbodzakey, Hope& Adoba, Prince& Cudjoe, Obed…[et al.]. 2016. Normal Non-HDL Cholesterol, Low Total Cholesterol, and HDL Cholesterol Levels in Sickle Cell Disease Patients in the Steady State: A Case-Control Study of Tema Metropolis. Journal of Lipids،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1108934
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ephraim, Richard K. D.…[et al.]. Normal Non-HDL Cholesterol, Low Total Cholesterol, and HDL Cholesterol Levels in Sickle Cell Disease Patients in the Steady State: A Case-Control Study of Tema Metropolis. Journal of Lipids No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1108934
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ephraim, Richard K. D.& Adu, Patrick& Ake, Edem& Agbodzakey, Hope& Adoba, Prince& Cudjoe, Obed…[et al.]. Normal Non-HDL Cholesterol, Low Total Cholesterol, and HDL Cholesterol Levels in Sickle Cell Disease Patients in the Steady State: A Case-Control Study of Tema Metropolis. Journal of Lipids. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1108934
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108934
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر