Normal Non-HDL Cholesterol, Low Total Cholesterol, and HDL Cholesterol Levels in Sickle Cell Disease Patients in the Steady State: A Case-Control Study of Tema Metropolis
Joint Authors
Adu, Patrick
Ephraim, Richard K. D.
Ake, Edem
Agbodzakey, Hope
Adoba, Prince
Cudjoe, Obed
Agoni, Clement
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-18
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Abnormal lipid homeostasis in sickle cell disease (SCD) is characterized by defects in plasma and erythrocyte lipids and may increase the risk of cardiovascular disease.
This study assessed the lipid profile and non-HDL cholesterol level of SCD patients.
Methods.
A hospital-based cross-sectional study was conducted in 50 SCD patients, in the steady state, aged 8–28 years, attending the SCD clinic, and 50 healthy volunteers between the ages of 8–38 years.
Serum lipids were determined by enzymatic methods and non-HDL cholesterol calculated by this formula: non-HDL-C = TC-HDL-C.
Results.
Total cholesterol (TC) ( p = 0.001 ) and high-density lipoprotein cholesterol (HDL-C) ( p < 0.0001 ) were significantly decreased in cases compared to controls.
The levels of non-HDL-C, low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) were similar among the participants.
The levels of decrease in TC and HDL were associated with whether a patient was SCD-SS or SCD-SC.
Systolic blood pressure and diastolic blood pressure were each significantly associated with increased VLDL [SBP, p = 0.01 , OR: 0.74 (CI: 0.6–0.93); DBP, p = 0.023 , OR: 1.45 (CI: 1.05–2.0)].
Conclusion.
Dyslipidemia is common among participants in this study.
It was more pronounced in the SCD-SS than in SCD-SC.
This dyslipidemia was associated with high VLDL as well as increased SBP and DBP.
American Psychological Association (APA)
Ephraim, Richard K. D.& Adu, Patrick& Ake, Edem& Agbodzakey, Hope& Adoba, Prince& Cudjoe, Obed…[et al.]. 2016. Normal Non-HDL Cholesterol, Low Total Cholesterol, and HDL Cholesterol Levels in Sickle Cell Disease Patients in the Steady State: A Case-Control Study of Tema Metropolis. Journal of Lipids،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1108934
Modern Language Association (MLA)
Ephraim, Richard K. D.…[et al.]. Normal Non-HDL Cholesterol, Low Total Cholesterol, and HDL Cholesterol Levels in Sickle Cell Disease Patients in the Steady State: A Case-Control Study of Tema Metropolis. Journal of Lipids No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1108934
American Medical Association (AMA)
Ephraim, Richard K. D.& Adu, Patrick& Ake, Edem& Agbodzakey, Hope& Adoba, Prince& Cudjoe, Obed…[et al.]. Normal Non-HDL Cholesterol, Low Total Cholesterol, and HDL Cholesterol Levels in Sickle Cell Disease Patients in the Steady State: A Case-Control Study of Tema Metropolis. Journal of Lipids. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1108934
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108934