In Vivo Investigation of ALBO-OS Scaffold Based on Hydroxyapatite and PLGA
المؤلفون المشاركون
Jokanović, Vukoman
Čolović, Božana
Marković, Dejan
Petrović, Milan
Jokanović, Milan
Milosavljević, Petar
Sopta, Jelena
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
A synthetic bone substitute based on calcium hydroxyapatite (CHA) and poly(lactic-co-glycolic) acid (PLGA), described in this paper, was synthesized to fulfill specific requirements like biodegradability, satisfying mechanical properties, optimal porosity and nanotopology, osteoinductive and osteoconductive properties, and so forth.
Structural and morphological properties of the new scaffold were analyzed by micro computed tomography and scanning electron microscopy, while its physicochemical properties were investigated by X-ray diffraction and infrared spectroscopy.
In vivo biological investigations of the synthesized scaffold were conducted over the cutaneous irritation and biofunctionality assays on rabbits and the test of acute systemic toxicity on mice.
The results showed that the scaffold is not irritant and that it does not exhibit any symptoms of acute toxicity.
Biofunctionality assays which include evaluation of the presence of various cells of immune response, the presence of neoangiogenesis, percentage of mineralization of newly formed bone, and fibroplasia in the tissue indicated that the new scaffold is suitable for the application in maxillofacial and dental surgery as a bone substitute.
Also, it showed significant advantages over commercial product Geistlich Bio-Oss® from the aspect of some parameters of immunological response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jokanović, Vukoman& Čolović, Božana& Marković, Dejan& Petrović, Milan& Jokanović, Milan& Milosavljević, Petar…[et al.]. 2016. In Vivo Investigation of ALBO-OS Scaffold Based on Hydroxyapatite and PLGA. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109139
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jokanović, Vukoman…[et al.]. In Vivo Investigation of ALBO-OS Scaffold Based on Hydroxyapatite and PLGA. Journal of Nanomaterials No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1109139
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jokanović, Vukoman& Čolović, Božana& Marković, Dejan& Petrović, Milan& Jokanović, Milan& Milosavljević, Petar…[et al.]. In Vivo Investigation of ALBO-OS Scaffold Based on Hydroxyapatite and PLGA. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109139
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1109139
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر