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In Vivo Investigation of ALBO-OS Scaffold Based on Hydroxyapatite and PLGA
Joint Authors
Jokanović, Vukoman
Čolović, Božana
Marković, Dejan
Petrović, Milan
Jokanović, Milan
Milosavljević, Petar
Sopta, Jelena
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A synthetic bone substitute based on calcium hydroxyapatite (CHA) and poly(lactic-co-glycolic) acid (PLGA), described in this paper, was synthesized to fulfill specific requirements like biodegradability, satisfying mechanical properties, optimal porosity and nanotopology, osteoinductive and osteoconductive properties, and so forth.
Structural and morphological properties of the new scaffold were analyzed by micro computed tomography and scanning electron microscopy, while its physicochemical properties were investigated by X-ray diffraction and infrared spectroscopy.
In vivo biological investigations of the synthesized scaffold were conducted over the cutaneous irritation and biofunctionality assays on rabbits and the test of acute systemic toxicity on mice.
The results showed that the scaffold is not irritant and that it does not exhibit any symptoms of acute toxicity.
Biofunctionality assays which include evaluation of the presence of various cells of immune response, the presence of neoangiogenesis, percentage of mineralization of newly formed bone, and fibroplasia in the tissue indicated that the new scaffold is suitable for the application in maxillofacial and dental surgery as a bone substitute.
Also, it showed significant advantages over commercial product Geistlich Bio-Oss® from the aspect of some parameters of immunological response.
American Psychological Association (APA)
Jokanović, Vukoman& Čolović, Božana& Marković, Dejan& Petrović, Milan& Jokanović, Milan& Milosavljević, Petar…[et al.]. 2016. In Vivo Investigation of ALBO-OS Scaffold Based on Hydroxyapatite and PLGA. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109139
Modern Language Association (MLA)
Jokanović, Vukoman…[et al.]. In Vivo Investigation of ALBO-OS Scaffold Based on Hydroxyapatite and PLGA. Journal of Nanomaterials No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1109139
American Medical Association (AMA)
Jokanović, Vukoman& Čolović, Božana& Marković, Dejan& Petrović, Milan& Jokanović, Milan& Milosavljević, Petar…[et al.]. In Vivo Investigation of ALBO-OS Scaffold Based on Hydroxyapatite and PLGA. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109139
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109139