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Redox-Responsive Nanophotosensitizer Composed of Chlorin e6-Conjugated Dextran for Photodynamic Treatment of Colon Cancer Cells
المؤلفون المشاركون
Chu, Chong Woo
Ryu, Je Ho
Jeong, Young-IL
Lee, Hye Lim
Kim, Hyun Yul
Son, Gyung Mo
Kim, Hyung Wook
Kang, Dae-Hwan
Kwak, Tae Won
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-04
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
We synthesized dextran-chlorin e6 conjugates having disulfide linkage for specific targeting of colonic region and cancer cells.
Reductive end group of dextran was treated with sodium borocyanohydride and conjugated with cystamine.
Cystamine end group was conjugated with carboxylic acid of chlorin e6 (DEX6ss).
DEX6ss conjugates were formed as spherical nanoparticles with small sizes less than 100 nm.
Chlorin e6 (Ce6) was specifically released from DEX6ss nanoparticles in the presence of dextranase or glutathione (GSH), indicating that DEX6ss nanoparticles have responsiveness against dextranase and redox-environment.
In dark-toxicity test using normal cells and cancer cells, Ce6 and DEX6ss nanoparticles were practically nontoxic.
Intracellular delivery of DEX6ss nanoparticles was significantly improved compared to Ce6 itself.
DEX6ss nanoparticles achieved significantly higher ROS production and phototoxicity against HCT116 colon cancer cells than Ce6 itself.
Furthermore, DEX6ss nanoparticles showed enhanced tumor targeting efficiency and longer retention in the tumor tissues at in vivo animal study with HCT116 tumor-bearing mice.
Furthermore, DEX6ss nanoparticles have responsiveness against colonic enzyme, dextranase, indicating that they have potential of colon-specific delivery and dextranase-specific drug delivery capacity.
We fabricated colon-specific and tumor-targetable nanophotosensitizer using DEX6ss conjugates.
They showed improved cellular uptake ratio, phototoxicity, and colon-specificity.
We suggest that DEX6ss nanoparticles can be considered as a promising candidate for PDT of colon cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chu, Chong Woo& Ryu, Je Ho& Jeong, Young-IL& Kwak, Tae Won& Lee, Hye Lim& Kim, Hyun Yul…[et al.]. 2016. Redox-Responsive Nanophotosensitizer Composed of Chlorin e6-Conjugated Dextran for Photodynamic Treatment of Colon Cancer Cells. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1109153
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chu, Chong Woo…[et al.]. Redox-Responsive Nanophotosensitizer Composed of Chlorin e6-Conjugated Dextran for Photodynamic Treatment of Colon Cancer Cells. Journal of Nanomaterials No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1109153
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chu, Chong Woo& Ryu, Je Ho& Jeong, Young-IL& Kwak, Tae Won& Lee, Hye Lim& Kim, Hyun Yul…[et al.]. Redox-Responsive Nanophotosensitizer Composed of Chlorin e6-Conjugated Dextran for Photodynamic Treatment of Colon Cancer Cells. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1109153
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1109153
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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