Synthesis of Cefixime and Azithromycin Nanoparticles: An Attempt to Enhance Their Antimicrobial Activity and Dissolution Rate
المؤلفون المشاركون
Khan, Farhat Ali
Zahoor, Muhammad
Islam, Noor Ul
Hameed, Rabia
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-06
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
In this study cefixime and azithromycin nanoparticles were prepared by antisolvent precipitation with syringe pump (APSP) and evaporator precipitation nanosuspension (EPN) methods.
The nanoparticles were characterized by XRD, FTIR, SEM, and TGA.
X-ray diffraction pattern of cefixime samples showed the amorphous form, while azithromycin samples showed crystalline form.
The FTIR spectra of parental drugs and synthesized nanoparticles have no major structural changes detected.
The SEM images showed that nanoparticles of both drugs have submicron sized and nanosized particles.
TGA analyses showed that above 30°C the decomposition of cefixime samples starts and their weight gradually decreases up to 600°C, while, in case of azithromycin, 30°C to 250°C, very small changes occur in weight; from above 250°C decomposition of the sample took place to a greater extent.
The antibacterial activities of raw drugs and prepared samples of nanoparticles were determined against Staphylococcus aureus, Shigella, E.
coli, and Salmonella typhi by agar well diffusion method.
Every time the nanoparticles samples showed better results than parental drugs.
The dissolution rates of raw drugs and prepared nanoparticles were also determined.
The results were always better for the synthesized nanoparticles than parental drug.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khan, Farhat Ali& Zahoor, Muhammad& Islam, Noor Ul& Hameed, Rabia. 2016. Synthesis of Cefixime and Azithromycin Nanoparticles: An Attempt to Enhance Their Antimicrobial Activity and Dissolution Rate. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109327
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khan, Farhat Ali…[et al.]. Synthesis of Cefixime and Azithromycin Nanoparticles: An Attempt to Enhance Their Antimicrobial Activity and Dissolution Rate. Journal of Nanomaterials No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1109327
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khan, Farhat Ali& Zahoor, Muhammad& Islam, Noor Ul& Hameed, Rabia. Synthesis of Cefixime and Azithromycin Nanoparticles: An Attempt to Enhance Their Antimicrobial Activity and Dissolution Rate. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109327
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1109327
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر