Synthesis of Cefixime and Azithromycin Nanoparticles: An Attempt to Enhance Their Antimicrobial Activity and Dissolution Rate
Joint Authors
Khan, Farhat Ali
Zahoor, Muhammad
Islam, Noor Ul
Hameed, Rabia
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In this study cefixime and azithromycin nanoparticles were prepared by antisolvent precipitation with syringe pump (APSP) and evaporator precipitation nanosuspension (EPN) methods.
The nanoparticles were characterized by XRD, FTIR, SEM, and TGA.
X-ray diffraction pattern of cefixime samples showed the amorphous form, while azithromycin samples showed crystalline form.
The FTIR spectra of parental drugs and synthesized nanoparticles have no major structural changes detected.
The SEM images showed that nanoparticles of both drugs have submicron sized and nanosized particles.
TGA analyses showed that above 30°C the decomposition of cefixime samples starts and their weight gradually decreases up to 600°C, while, in case of azithromycin, 30°C to 250°C, very small changes occur in weight; from above 250°C decomposition of the sample took place to a greater extent.
The antibacterial activities of raw drugs and prepared samples of nanoparticles were determined against Staphylococcus aureus, Shigella, E.
coli, and Salmonella typhi by agar well diffusion method.
Every time the nanoparticles samples showed better results than parental drugs.
The dissolution rates of raw drugs and prepared nanoparticles were also determined.
The results were always better for the synthesized nanoparticles than parental drug.
American Psychological Association (APA)
Khan, Farhat Ali& Zahoor, Muhammad& Islam, Noor Ul& Hameed, Rabia. 2016. Synthesis of Cefixime and Azithromycin Nanoparticles: An Attempt to Enhance Their Antimicrobial Activity and Dissolution Rate. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109327
Modern Language Association (MLA)
Khan, Farhat Ali…[et al.]. Synthesis of Cefixime and Azithromycin Nanoparticles: An Attempt to Enhance Their Antimicrobial Activity and Dissolution Rate. Journal of Nanomaterials No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1109327
American Medical Association (AMA)
Khan, Farhat Ali& Zahoor, Muhammad& Islam, Noor Ul& Hameed, Rabia. Synthesis of Cefixime and Azithromycin Nanoparticles: An Attempt to Enhance Their Antimicrobial Activity and Dissolution Rate. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109327
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109327