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An Innovative Cell Microincubator for Drug Discovery Based on 3D Silicon Structures
المؤلفون المشاركون
Aredia, Francesca
Carpignano, Francesca
Surdo, Salvatore
Barillaro, Giuseppe
Mazzini, Giuliano
Merlo, Sabina
Scovassi, Anna Ivana
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-15
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
We recently employed three-dimensional (3D) silicon microstructures (SMSs) consisting in arrays of 3 μm-thick silicon walls separated by 50 μm-deep, 5 μm-wide gaps, as microincubators for monitoring the biomechanical properties of tumor cells.
They were here applied to investigate the in vitro behavior of HT1080 human fibrosarcoma cells driven to apoptosis by the chemotherapeutic drug Bleomycin.
Our results, obtained by fluorescence microscopy, demonstrated that HT1080 cells exhibited a great ability to colonize the narrow gaps.
Remarkably, HT1080 cells grown on 3D-SMS, when treated with the DNA damaging agent Bleomycin under conditions leading to apoptosis, tended to shrink, reducing their volume and mimicking the normal behavior of apoptotic cells, and were prone to leave the gaps.
Finally, we performed label-free detection of cells adherent to the vertical silicon wall, inside the gap of 3D-SMS, by exploiting optical low coherence reflectometry using infrared, low power radiation.
This kind of approach may become a new tool for increasing automation in the drug discovery area.
Our results open new perspectives in view of future applications of the 3D-SMS as the core element of a lab-on-a-chip suitable for screening the effect of new molecules potentially able to kill tumor cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Aredia, Francesca& Carpignano, Francesca& Surdo, Salvatore& Barillaro, Giuseppe& Mazzini, Giuliano& Scovassi, Anna Ivana…[et al.]. 2016. An Innovative Cell Microincubator for Drug Discovery Based on 3D Silicon Structures. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109411
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Aredia, Francesca…[et al.]. An Innovative Cell Microincubator for Drug Discovery Based on 3D Silicon Structures. Journal of Nanomaterials No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1109411
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Aredia, Francesca& Carpignano, Francesca& Surdo, Salvatore& Barillaro, Giuseppe& Mazzini, Giuliano& Scovassi, Anna Ivana…[et al.]. An Innovative Cell Microincubator for Drug Discovery Based on 3D Silicon Structures. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109411
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1109411
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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