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Hepatoprotective Activity of Herbal Composition SAL, a Standardize Blend Comprised of Schisandra chinensis, Artemisia capillaris, and Aloe barbadensis
المؤلفون المشاركون
Lee, Young-Chul
Yimam, Mesfin
Moore, Breanna
Jiao, Ping
Kim, Hyun-Jin
Nam, Jeong-Bum
Kim, Mi-Ran
Cleveland, Sabrina
Chu, Min
Jung, Gayoung
Do, Seon Gil
Jia, Qi
Hyun, Eujin
Hong, Mei
المصدر
Journal of Nutrition and Metabolism
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-15
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Some botanicals have been reported to possess antioxidative activities acting as scavengers of free radicals rendering their usage in herbal medicine.
Here we describe the potential use of “SAL,” a standardized blend comprised of three extracts from Schisandra chinensis, Artemisia capillaris, and Aloe barbadensis, in mitigating chemically induced acute liver toxicities.
Acetaminophen and carbon tetrachloride induced acute liver toxicity models in mice were utilized.
Hepatic functional tests from serum collected at T24 and hepatic glutathione and superoxide dismutases from liver homogenates were evaluated.
Histopathology analysis and merit of blending 3 standardized extracts were also confirmed.
Statistically significant and dose-correlated inhibitions in serum ALT ranging from 52.5% ( p = 0.004 ) to 34.6% ( p = 0.05 ) in the APAP and 46.3% ( p < 0.001 ) to 29.9% ( p = 0.02 ) in the CCl4 models were observed for SAL administered at doses of 400–250 mg/kg.
Moreover, SAL resulted in up to 60.6% and 80.2% reductions in serums AST and bile acid, respectively.
The composition replenished depleted hepatic glutathione in association with an increase of hepatic superoxide dismutase.
Unexpected synergistic protection from liver damage was also observed.
Therefore, the composition SAL could be potentially utilized as an effective hepatic-detoxification agent for the protection from liver damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yimam, Mesfin& Jiao, Ping& Moore, Breanna& Hong, Mei& Cleveland, Sabrina& Chu, Min…[et al.]. 2016. Hepatoprotective Activity of Herbal Composition SAL, a Standardize Blend Comprised of Schisandra chinensis, Artemisia capillaris, and Aloe barbadensis. Journal of Nutrition and Metabolism،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109586
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yimam, Mesfin…[et al.]. Hepatoprotective Activity of Herbal Composition SAL, a Standardize Blend Comprised of Schisandra chinensis, Artemisia capillaris, and Aloe barbadensis. Journal of Nutrition and Metabolism No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1109586
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yimam, Mesfin& Jiao, Ping& Moore, Breanna& Hong, Mei& Cleveland, Sabrina& Chu, Min…[et al.]. Hepatoprotective Activity of Herbal Composition SAL, a Standardize Blend Comprised of Schisandra chinensis, Artemisia capillaris, and Aloe barbadensis. Journal of Nutrition and Metabolism. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109586
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1109586
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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