Omega-3 Fatty Acids: Possible Neuroprotective Mechanisms in the Model of Global Ischemia in Rats
المؤلفون المشاركون
Brito, Gerly Anne de Castro
Siqueira, Rafaelly
Neves, Kelly Rose
Nobre, Maria Elizabeth Pereira
Correia, Alyne Oliveira
Mendonça, Francisco Nilson Maciel
Uchoa, Luiz Ricardo Araújo
Vasconcelos, Jessica Tamara Nunes
de Araújo, Carlos Ney Alencar
Viana, Glauce Socorro de Barros
Cerqueira, Gilberto Santos
Arida, Ricardo Mario
المصدر
Journal of Nutrition and Metabolism
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-24
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
Omega-3 (ω3) administration was shown to protect against hypoxic-ischemic injury.
The objectives were to study the neuroprotective effects of ω3, in a model of global ischemia.
Methods.
Male Wistar rats were subjected to carotid occlusion (30 min), followed by reperfusion.
The groups were SO, untreated ischemic and ischemic treated rats with ω3 (5 and 10 mg/kg, 7 days).
The SO and untreated ischemic animals were orally treated with 1% cremophor and, 1 h after the last administration, they were behaviorally tested and euthanized for neurochemical (DA, DOPAC, and NE determinations), histological (Fluoro jade staining), and immunohistochemical (TNF-alpha, COX-2 and iNOS) evaluations.
The data were analyzed by ANOVA and Newman-Keuls as the post hoc test.
Results.
Ischemia increased the locomotor activity and rearing behavior that were partly reversed by ω3.
Ischemia decreased striatal DA and DOPAC contents and increased NE contents, effects reversed by ω3.
This drug protected hippocampal neuron degeneration, as observed by Fluoro-Jade staining, and the increased immunostainings for TNF-alpha, COX-2, and iNOS were partly or totally blocked by ω3.
Conclusion.
This study showed a neuroprotective effect of ω3, in great part due to its anti-inflammatory properties, stimulating translational studies focusing on its use in clinic for stroke managing.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nobre, Maria Elizabeth Pereira& Correia, Alyne Oliveira& Mendonça, Francisco Nilson Maciel& Uchoa, Luiz Ricardo Araújo& Vasconcelos, Jessica Tamara Nunes& de Araújo, Carlos Ney Alencar…[et al.]. 2016. Omega-3 Fatty Acids: Possible Neuroprotective Mechanisms in the Model of Global Ischemia in Rats. Journal of Nutrition and Metabolism،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1109605
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nobre, Maria Elizabeth Pereira…[et al.]. Omega-3 Fatty Acids: Possible Neuroprotective Mechanisms in the Model of Global Ischemia in Rats. Journal of Nutrition and Metabolism No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1109605
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nobre, Maria Elizabeth Pereira& Correia, Alyne Oliveira& Mendonça, Francisco Nilson Maciel& Uchoa, Luiz Ricardo Araújo& Vasconcelos, Jessica Tamara Nunes& de Araújo, Carlos Ney Alencar…[et al.]. Omega-3 Fatty Acids: Possible Neuroprotective Mechanisms in the Model of Global Ischemia in Rats. Journal of Nutrition and Metabolism. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1109605
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1109605
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر