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Effects of 8-Prenylnaringenin and Whole-Body Vibration Therapy on a Rat Model of Osteopenia
المؤلفون المشاركون
Tezval, M.
Hoffmann, D. B.
Komrakova, M.
Griesel, Markus H.
Brockhusen, Bastian
Menger, Bjoern
Wassmann, Marco
Stürmer, Klaus Michael
Sehmisch, S.
المصدر
Journal of Nutrition and Metabolism
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
8-Prenylnaringenin (8-PN) is the phytoestrogen with the highest affinity for estrogen receptor-α (ER-α), which is required to maintain BMD.
The osteoprotective properties of 8-PN have been demonstrated previously in tibiae.
We used a rat osteopenia model to perform the first investigation of 8-PN with whole-body vertical vibration (WBVV).
Study Design.
Ovariectomy was performed on 52 of 64 Sprague-Dawley rats.
Five weeks after ovariectomy, one group received daily injections (sc) of 8-PN (1.77 mg/kg) for 10 weeks; a second group was treated with both 8-PN and WBVV (twice a day, 15 min, 35 Hz, amplitude 0.47 mm).
Other groups received either only WBVV or no treatment.
Methods.
The rats were sacrificed 15 weeks after ovariectomy.
Lumbar vertebrae and femora were removed for biomechanical and morphological assessment.
Results.
8-PN at a cancer-safe dose did not cause fundamental improvements in osteoporotic bones.
Treatment with 8-PN caused a slight increase in uterine wet weight.
Combined therapy using WBVV and 8-PN showed no significant improvements in bone structure and biomechanical properties.
Conclusion.
We cannot confirm the osteoprotective effects of 8-PN at a cancer-safe dose in primary affected osteoporotic bones.
Higher concentrations of 8-PN are not advisable for safety reasons.
Adjunctive therapy with WBVV demonstrates no convincing effects on bones.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hoffmann, D. B.& Griesel, Markus H.& Brockhusen, Bastian& Tezval, M.& Komrakova, M.& Menger, Bjoern…[et al.]. 2016. Effects of 8-Prenylnaringenin and Whole-Body Vibration Therapy on a Rat Model of Osteopenia. Journal of Nutrition and Metabolism،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109609
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hoffmann, D. B.…[et al.]. Effects of 8-Prenylnaringenin and Whole-Body Vibration Therapy on a Rat Model of Osteopenia. Journal of Nutrition and Metabolism No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1109609
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hoffmann, D. B.& Griesel, Markus H.& Brockhusen, Bastian& Tezval, M.& Komrakova, M.& Menger, Bjoern…[et al.]. Effects of 8-Prenylnaringenin and Whole-Body Vibration Therapy on a Rat Model of Osteopenia. Journal of Nutrition and Metabolism. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109609
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1109609
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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