TIMP-1 as well as Microvessel Invasion and High Nuclear Grade Is a Significant Determinant Factor for Extension of Tumor Diameter in Localized RCC
المؤلفون المشاركون
Takahashi, Satoru
Kawata, Nozomu
Yamaguchi, Kenya
Igarashi, Tomohiro
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-25
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objectives.
To clarify what kind of pathological factor is necessary for the extension of tumor diameter in localized RCC, we studied localized RCC patients.
Methods.
We retrospectively reviewed medical records of 237 RCC patients in our institute who underwent nephrectomy.
We performed immune histological analysis of MMP-2, MMP-9, TIMP-1, TIMP-2, and MT-MMP-1 for all samples.
Results.
Among the clinicopathological factors, multivariate analysis revealed nuclear grade; TIMP-2 and MT-MMP-1 were independent prognostic factors of localized RCC (risk ratio 1.50, p = 0.037 , risk ratio 1.12, p = 0.008 , and risk ratio 1.84, p = 0.045 , resp.).
By the multiple logistic regression analysis among pT1a versus pT1b, TIMP-1 was an independent factor (risk ratio 3.30, p = 0.010 ) whereas all pT1 versus pT2a and all pT1 + pT2a versus pT2b high nuclear grade (risk ratio 5.15, p = 0.0015 ) and Micro vessel invasion (MVI, risk ratio 3.08, p = 0.002 ) were independent factors.
For all pT1 + pT2a versus pT2b, nuclear grade (risk ratio 3.39, p = 0.020 ) and MVI (risk ratio 2.91, p = 0.018 ) were independent factors.
Conclusion.
Higher expression of TIMP-1 is necessary for advancement tumor diameter from pT1a to pT1b, and a process of tumor diameter extension beyond pT1 and pT2a category needs presence of MVI and high nuclear grade.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kawata, Nozomu& Yamaguchi, Kenya& Igarashi, Tomohiro& Takahashi, Satoru. 2016. TIMP-1 as well as Microvessel Invasion and High Nuclear Grade Is a Significant Determinant Factor for Extension of Tumor Diameter in Localized RCC. Journal of Oncology،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1109702
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kawata, Nozomu…[et al.]. TIMP-1 as well as Microvessel Invasion and High Nuclear Grade Is a Significant Determinant Factor for Extension of Tumor Diameter in Localized RCC. Journal of Oncology No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1109702
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kawata, Nozomu& Yamaguchi, Kenya& Igarashi, Tomohiro& Takahashi, Satoru. TIMP-1 as well as Microvessel Invasion and High Nuclear Grade Is a Significant Determinant Factor for Extension of Tumor Diameter in Localized RCC. Journal of Oncology. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1109702
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1109702
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر