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TIMP-1 as well as Microvessel Invasion and High Nuclear Grade Is a Significant Determinant Factor for Extension of Tumor Diameter in Localized RCC
Joint Authors
Takahashi, Satoru
Kawata, Nozomu
Yamaguchi, Kenya
Igarashi, Tomohiro
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objectives.
To clarify what kind of pathological factor is necessary for the extension of tumor diameter in localized RCC, we studied localized RCC patients.
Methods.
We retrospectively reviewed medical records of 237 RCC patients in our institute who underwent nephrectomy.
We performed immune histological analysis of MMP-2, MMP-9, TIMP-1, TIMP-2, and MT-MMP-1 for all samples.
Results.
Among the clinicopathological factors, multivariate analysis revealed nuclear grade; TIMP-2 and MT-MMP-1 were independent prognostic factors of localized RCC (risk ratio 1.50, p = 0.037 , risk ratio 1.12, p = 0.008 , and risk ratio 1.84, p = 0.045 , resp.).
By the multiple logistic regression analysis among pT1a versus pT1b, TIMP-1 was an independent factor (risk ratio 3.30, p = 0.010 ) whereas all pT1 versus pT2a and all pT1 + pT2a versus pT2b high nuclear grade (risk ratio 5.15, p = 0.0015 ) and Micro vessel invasion (MVI, risk ratio 3.08, p = 0.002 ) were independent factors.
For all pT1 + pT2a versus pT2b, nuclear grade (risk ratio 3.39, p = 0.020 ) and MVI (risk ratio 2.91, p = 0.018 ) were independent factors.
Conclusion.
Higher expression of TIMP-1 is necessary for advancement tumor diameter from pT1a to pT1b, and a process of tumor diameter extension beyond pT1 and pT2a category needs presence of MVI and high nuclear grade.
American Psychological Association (APA)
Kawata, Nozomu& Yamaguchi, Kenya& Igarashi, Tomohiro& Takahashi, Satoru. 2016. TIMP-1 as well as Microvessel Invasion and High Nuclear Grade Is a Significant Determinant Factor for Extension of Tumor Diameter in Localized RCC. Journal of Oncology،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1109702
Modern Language Association (MLA)
Kawata, Nozomu…[et al.]. TIMP-1 as well as Microvessel Invasion and High Nuclear Grade Is a Significant Determinant Factor for Extension of Tumor Diameter in Localized RCC. Journal of Oncology No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1109702
American Medical Association (AMA)
Kawata, Nozomu& Yamaguchi, Kenya& Igarashi, Tomohiro& Takahashi, Satoru. TIMP-1 as well as Microvessel Invasion and High Nuclear Grade Is a Significant Determinant Factor for Extension of Tumor Diameter in Localized RCC. Journal of Oncology. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1109702
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109702