High MMP-9 Expression May Contribute to Retroprosthetic Membrane Formation after KPro Implantation in Rabbit Corneal Alkali Burn Model
المؤلفون المشاركون
Belin, Michael Wellington
Gao, Minghong
Sang, Wei
Liu, Fuying
Yu, Hai
Zhou, Runhai
Zloty, Peter
Chen, Yingxin
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-01
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purpose.
To evaluate aqueous humor MMP-9 levels in alkali-burned rabbit cornea following KPr implantation and their roles in RPMs formation.
Methods.
Left eyes of 36 rabbits received a deep corneal alkali wound.
12 corneas were implanted with KPro and the other 24 control corneas were either penetrating keratoplasty or left without keratoplasty.
Aqueous humor MMP-9 and TIMP-1 levels were determined and RPMs were obtained for histopathological and ultrastructural examination.
Results.
Alkali exposure induced significant increase in aqueous humor MMP-9 level and the data were further enhanced by KPro implantation.
By contrast, TMIP-1 levels in aqueous humor showed a decreased trend following corneal alkali burn and KPro surgery.
RPMs were developed in 5 out of 10 cases of KPro successfully implanted eyes.
Histopathology showed the presence of a large number of fibroblasts and collagen fibers arranged irregularly with inflammatory cells infiltration, and an ingrowth of new blood vessels in this retrokeratoprosthesis fibrous tissue.
Immunohistochemical analysis showed positive stain of RPMs for both MMP-9 and TIMP-1.
Aqueous humor MMP-9 levels were significantly higher in RPM group postoperatively, while TIMP-1 levels were comparatively lower than that of No-RPM group.
Conclusions.
Our study evidenced the potential pathophysiological role of MMP-9 expression in RPM formation following KPro implantation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gao, Minghong& Sang, Wei& Liu, Fuying& Yu, Hai& Zhou, Runhai& Belin, Michael Wellington…[et al.]. 2016. High MMP-9 Expression May Contribute to Retroprosthetic Membrane Formation after KPro Implantation in Rabbit Corneal Alkali Burn Model. Journal of Ophthalmology،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109813
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gao, Minghong…[et al.]. High MMP-9 Expression May Contribute to Retroprosthetic Membrane Formation after KPro Implantation in Rabbit Corneal Alkali Burn Model. Journal of Ophthalmology No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1109813
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gao, Minghong& Sang, Wei& Liu, Fuying& Yu, Hai& Zhou, Runhai& Belin, Michael Wellington…[et al.]. High MMP-9 Expression May Contribute to Retroprosthetic Membrane Formation after KPro Implantation in Rabbit Corneal Alkali Burn Model. Journal of Ophthalmology. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109813
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1109813
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر