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High MMP-9 Expression May Contribute to Retroprosthetic Membrane Formation after KPro Implantation in Rabbit Corneal Alkali Burn Model
Joint Authors
Belin, Michael Wellington
Gao, Minghong
Sang, Wei
Liu, Fuying
Yu, Hai
Zhou, Runhai
Zloty, Peter
Chen, Yingxin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
To evaluate aqueous humor MMP-9 levels in alkali-burned rabbit cornea following KPr implantation and their roles in RPMs formation.
Methods.
Left eyes of 36 rabbits received a deep corneal alkali wound.
12 corneas were implanted with KPro and the other 24 control corneas were either penetrating keratoplasty or left without keratoplasty.
Aqueous humor MMP-9 and TIMP-1 levels were determined and RPMs were obtained for histopathological and ultrastructural examination.
Results.
Alkali exposure induced significant increase in aqueous humor MMP-9 level and the data were further enhanced by KPro implantation.
By contrast, TMIP-1 levels in aqueous humor showed a decreased trend following corneal alkali burn and KPro surgery.
RPMs were developed in 5 out of 10 cases of KPro successfully implanted eyes.
Histopathology showed the presence of a large number of fibroblasts and collagen fibers arranged irregularly with inflammatory cells infiltration, and an ingrowth of new blood vessels in this retrokeratoprosthesis fibrous tissue.
Immunohistochemical analysis showed positive stain of RPMs for both MMP-9 and TIMP-1.
Aqueous humor MMP-9 levels were significantly higher in RPM group postoperatively, while TIMP-1 levels were comparatively lower than that of No-RPM group.
Conclusions.
Our study evidenced the potential pathophysiological role of MMP-9 expression in RPM formation following KPro implantation.
American Psychological Association (APA)
Gao, Minghong& Sang, Wei& Liu, Fuying& Yu, Hai& Zhou, Runhai& Belin, Michael Wellington…[et al.]. 2016. High MMP-9 Expression May Contribute to Retroprosthetic Membrane Formation after KPro Implantation in Rabbit Corneal Alkali Burn Model. Journal of Ophthalmology،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109813
Modern Language Association (MLA)
Gao, Minghong…[et al.]. High MMP-9 Expression May Contribute to Retroprosthetic Membrane Formation after KPro Implantation in Rabbit Corneal Alkali Burn Model. Journal of Ophthalmology No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1109813
American Medical Association (AMA)
Gao, Minghong& Sang, Wei& Liu, Fuying& Yu, Hai& Zhou, Runhai& Belin, Michael Wellington…[et al.]. High MMP-9 Expression May Contribute to Retroprosthetic Membrane Formation after KPro Implantation in Rabbit Corneal Alkali Burn Model. Journal of Ophthalmology. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109813
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109813