Comparison of Subconjunctival Mitomycin C and 5-Fluorouracil Injection for Needle Revision of Early Failed Trabeculectomy Blebs

المؤلفون المشاركون

Liu, Wei
Wang, Jianrong
Zhang, Miaomiao
Tao, Yuan
Sun, Yan

المصدر

Journal of Ophthalmology

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-02-16

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الطب البشري

الملخص EN

Background.

To compare the efficacy of needle revision with 5-fluorouracil (5-FU) and mitomycin C (MMC) on dysfunctional filtration blebs shortly after trabeculectomy.

Methods.

It is a prospective randomized study comparing needle revision augmented with MMC or 5-FU for failed trabeculectomy blebs.

Results.

To date 71 patients (75 eyes) have been enrolled, 40 eyes in the MMC group and 35 in the 5-FU group.

68 patients (72 eyes) have completed 12-month follow-up, 38 eyes in the MMC group and 34 in the 5-FU group.

The mean IOP before and that after needle revision in the MMC group were 26.5 ± 4.3 mmHg and 11.3 ± 3 .4 mmHg, respectively ( P < 0.05 ), and in the 5-FU group were 27.1 ± 3.8 mmHg and 10.9 ± 3.4 mmHg, respectively ( P < 0.05 ).

At 12-month follow-up, complete success rates were 57.5% for MMC group and 34.3% for 5-FU group ( P = 0.042 ; log-rank test) and 75% and 60% ( P = 0.145 ; log-rank test), respectively, for the qualified success.

Complication rates between the two groups were not statistically different ( P > 0.05 ).

Conclusions.

Needle revision and subconjunctival MMC injection were more effective than needling and subconjunctival 5-FU injection for early dysfunctional filtration blebs after trabeculectomies.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Liu, Wei& Wang, Jianrong& Zhang, Miaomiao& Tao, Yuan& Sun, Yan. 2016. Comparison of Subconjunctival Mitomycin C and 5-Fluorouracil Injection for Needle Revision of Early Failed Trabeculectomy Blebs. Journal of Ophthalmology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1109940

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Liu, Wei…[et al.]. Comparison of Subconjunctival Mitomycin C and 5-Fluorouracil Injection for Needle Revision of Early Failed Trabeculectomy Blebs. Journal of Ophthalmology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1109940

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Liu, Wei& Wang, Jianrong& Zhang, Miaomiao& Tao, Yuan& Sun, Yan. Comparison of Subconjunctival Mitomycin C and 5-Fluorouracil Injection for Needle Revision of Early Failed Trabeculectomy Blebs. Journal of Ophthalmology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1109940

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1109940