Comparison of Subconjunctival Mitomycin C and 5-Fluorouracil Injection for Needle Revision of Early Failed Trabeculectomy Blebs

Abstract EN

Background.

To compare the efficacy of needle revision with 5-fluorouracil (5-FU) and mitomycin C (MMC) on dysfunctional filtration blebs shortly after trabeculectomy.

Methods.

It is a prospective randomized study comparing needle revision augmented with MMC or 5-FU for failed trabeculectomy blebs.

Results.

To date 71 patients (75 eyes) have been enrolled, 40 eyes in the MMC group and 35 in the 5-FU group.

68 patients (72 eyes) have completed 12-month follow-up, 38 eyes in the MMC group and 34 in the 5-FU group.

The mean IOP before and that after needle revision in the MMC group were 26.5 ± 4.3 mmHg and 11.3 ± 3 .4 mmHg, respectively ( P < 0.05 ), and in the 5-FU group were 27.1 ± 3.8 mmHg and 10.9 ± 3.4 mmHg, respectively ( P < 0.05 ).

At 12-month follow-up, complete success rates were 57.5% for MMC group and 34.3% for 5-FU group ( P = 0.042 ; log-rank test) and 75% and 60% ( P = 0.145 ; log-rank test), respectively, for the qualified success.

Complication rates between the two groups were not statistically different ( P > 0.05 ).

Conclusions.

Needle revision and subconjunctival MMC injection were more effective than needling and subconjunctival 5-FU injection for early dysfunctional filtration blebs after trabeculectomies.