Therapeutic Effect of Intrastromal Voriconazole, Topical Voriconazole, and Topical Natamycin on Fusarium Keratitis in Rabbit
المؤلفون المشاركون
Nejabat, Mahmood
Yaqubi, Nafiseh
Khosravi, Amir
Salouti, Ramin
Ashraf, Mohamad J.
Zomorodian, Kamiar
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-19
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Purpose.
Evaluating the therapeutic effect of topical and intrastromal voriconazole and topical natamycin on Fusarium keratitis.
Methods.
24 rabbits were selected.
The stroma of their corneas was inoculated with suspension of Fusarium solani species complex.
Seven days after injection they were divided into 4 groups randomly: the first group was treated with topical voriconazole (TV) 1% for one week, the second one with one-time intrastromal injection of voriconazole (ISV) 50 microgram/0.1 mL, and the third group with topical gel of natamycin (TN) for one week, and the last one did not receive any antifungal treatment.
Finally the eyes were enucleated and sclerocorneal buttons were sent for histological and microbiological examinations.
Results.
After treatment the ISV group and TN group showed significantly lower clinical score and colony forming units than the control group (P=0.040 and P=0.026, resp.), but there was statistically no significant difference between control and TV groups (P=0.249) or between ISV and TN groups (P=0.665).
In pathological evaluation, fewer chronic inflammations were reported in 2 of the 3 buttons from TV group and 3 of the 3 buttons from ISV and TN groups in comparison with the control group.
Conclusion.
Intrastromal injection of voriconazole seems to be effective in treatment of Fusarium keratitis as much as topical natamycin and these are more effective than topical voriconazole.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nejabat, Mahmood& Yaqubi, Nafiseh& Khosravi, Amir& Zomorodian, Kamiar& Ashraf, Mohamad J.& Salouti, Ramin. 2016. Therapeutic Effect of Intrastromal Voriconazole, Topical Voriconazole, and Topical Natamycin on Fusarium Keratitis in Rabbit. Journal of Ophthalmology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1110108
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nejabat, Mahmood…[et al.]. Therapeutic Effect of Intrastromal Voriconazole, Topical Voriconazole, and Topical Natamycin on Fusarium Keratitis in Rabbit. Journal of Ophthalmology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1110108
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nejabat, Mahmood& Yaqubi, Nafiseh& Khosravi, Amir& Zomorodian, Kamiar& Ashraf, Mohamad J.& Salouti, Ramin. Therapeutic Effect of Intrastromal Voriconazole, Topical Voriconazole, and Topical Natamycin on Fusarium Keratitis in Rabbit. Journal of Ophthalmology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1110108
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1110108
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر