Therapeutic Effect of Intrastromal Voriconazole, Topical Voriconazole, and Topical Natamycin on Fusarium Keratitis in Rabbit
Joint Authors
Nejabat, Mahmood
Yaqubi, Nafiseh
Khosravi, Amir
Salouti, Ramin
Ashraf, Mohamad J.
Zomorodian, Kamiar
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
Evaluating the therapeutic effect of topical and intrastromal voriconazole and topical natamycin on Fusarium keratitis.
Methods.
24 rabbits were selected.
The stroma of their corneas was inoculated with suspension of Fusarium solani species complex.
Seven days after injection they were divided into 4 groups randomly: the first group was treated with topical voriconazole (TV) 1% for one week, the second one with one-time intrastromal injection of voriconazole (ISV) 50 microgram/0.1 mL, and the third group with topical gel of natamycin (TN) for one week, and the last one did not receive any antifungal treatment.
Finally the eyes were enucleated and sclerocorneal buttons were sent for histological and microbiological examinations.
Results.
After treatment the ISV group and TN group showed significantly lower clinical score and colony forming units than the control group (P=0.040 and P=0.026, resp.), but there was statistically no significant difference between control and TV groups (P=0.249) or between ISV and TN groups (P=0.665).
In pathological evaluation, fewer chronic inflammations were reported in 2 of the 3 buttons from TV group and 3 of the 3 buttons from ISV and TN groups in comparison with the control group.
Conclusion.
Intrastromal injection of voriconazole seems to be effective in treatment of Fusarium keratitis as much as topical natamycin and these are more effective than topical voriconazole.
American Psychological Association (APA)
Nejabat, Mahmood& Yaqubi, Nafiseh& Khosravi, Amir& Zomorodian, Kamiar& Ashraf, Mohamad J.& Salouti, Ramin. 2016. Therapeutic Effect of Intrastromal Voriconazole, Topical Voriconazole, and Topical Natamycin on Fusarium Keratitis in Rabbit. Journal of Ophthalmology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1110108
Modern Language Association (MLA)
Nejabat, Mahmood…[et al.]. Therapeutic Effect of Intrastromal Voriconazole, Topical Voriconazole, and Topical Natamycin on Fusarium Keratitis in Rabbit. Journal of Ophthalmology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1110108
American Medical Association (AMA)
Nejabat, Mahmood& Yaqubi, Nafiseh& Khosravi, Amir& Zomorodian, Kamiar& Ashraf, Mohamad J.& Salouti, Ramin. Therapeutic Effect of Intrastromal Voriconazole, Topical Voriconazole, and Topical Natamycin on Fusarium Keratitis in Rabbit. Journal of Ophthalmology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1110108
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110108