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Association of Trabecular Bone Score with Inflammation and Adiposity in Patients with Psoriasis: Effect of Adalimumab Therapy
المؤلفون المشاركون
Ubilla, Begoña
Gonzalez-Gay, Miguel A.
Hernández, José L.
Ruiz, Sheila
Sierra, Isabel
Mijares, Verónica
González-López, Marcos A.
Armesto, Susana
Corrales, Alfonso
Pons, Enar
Fuentevilla, Patricia
González-Vela, Carmen
Blanco, Ricardo
Pina, Trinitario
López-Mejías, Raquel
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-12
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Studies on trabecular bone score (TBS) in psoriasis are lacking.
We aim to assess the association between TBS and inflammation, metabolic syndrome features, and serum adipokines in 29 nondiabetic patients with psoriasis without arthritis, before and after 6-month adalimumab therapy.
For that purpose, adjusted partial correlations and stepwise multivariable linear regression analysis were performed.
No correlation was found between TBS and disease severity.
TBS was negatively associated with weight, BMI, waist perimeter, fat percentage, and systolic and diastolic blood pressure before and after adalimumab.
After 6 months of therapy, a negative correlation between TBS and insulin resistance ( p = 0.02 ) and leptin ( p = 0.01 ) and a positive correlation with adiponectin were found ( p = 0.01 ).
The best set of predictors for TBS values at baseline were female sex ( p = 0.015 ), age ( p = 0.05 ), and BMI ( p = 0.001 ).
The best set of predictors for TBS following 6 months of biologic therapy were age ( p = 0.001 ), BMI ( p < 0.0001 ), and serum adiponectin levels ( p = 0.027 ).
In conclusion, in nondiabetic patients with moderate-to-severe psoriasis, TBS correlates with metabolic syndrome features and inflammation.
This association is still present after 6 months of adalimumab therapy.
Moreover, serum adiponectin levels seem to be an independent variable related to TBS values, after adalimumab therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hernández, José L.& López-Mejías, Raquel& Blanco, Ricardo& Pina, Trinitario& Ruiz, Sheila& Sierra, Isabel…[et al.]. 2016. Association of Trabecular Bone Score with Inflammation and Adiposity in Patients with Psoriasis: Effect of Adalimumab Therapy. Journal of Osteoporosis،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1110162
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hernández, José L.…[et al.]. Association of Trabecular Bone Score with Inflammation and Adiposity in Patients with Psoriasis: Effect of Adalimumab Therapy. Journal of Osteoporosis No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1110162
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hernández, José L.& López-Mejías, Raquel& Blanco, Ricardo& Pina, Trinitario& Ruiz, Sheila& Sierra, Isabel…[et al.]. Association of Trabecular Bone Score with Inflammation and Adiposity in Patients with Psoriasis: Effect of Adalimumab Therapy. Journal of Osteoporosis. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1110162
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1110162
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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