Association of Trabecular Bone Score with Inflammation and Adiposity in Patients with Psoriasis: Effect of Adalimumab Therapy
Joint Authors
Ubilla, Begoña
Gonzalez-Gay, Miguel A.
Hernández, José L.
Ruiz, Sheila
Sierra, Isabel
Mijares, Verónica
González-López, Marcos A.
Armesto, Susana
Corrales, Alfonso
Pons, Enar
Fuentevilla, Patricia
González-Vela, Carmen
Blanco, Ricardo
Pina, Trinitario
López-Mejías, Raquel
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Studies on trabecular bone score (TBS) in psoriasis are lacking.
We aim to assess the association between TBS and inflammation, metabolic syndrome features, and serum adipokines in 29 nondiabetic patients with psoriasis without arthritis, before and after 6-month adalimumab therapy.
For that purpose, adjusted partial correlations and stepwise multivariable linear regression analysis were performed.
No correlation was found between TBS and disease severity.
TBS was negatively associated with weight, BMI, waist perimeter, fat percentage, and systolic and diastolic blood pressure before and after adalimumab.
After 6 months of therapy, a negative correlation between TBS and insulin resistance ( p = 0.02 ) and leptin ( p = 0.01 ) and a positive correlation with adiponectin were found ( p = 0.01 ).
The best set of predictors for TBS values at baseline were female sex ( p = 0.015 ), age ( p = 0.05 ), and BMI ( p = 0.001 ).
The best set of predictors for TBS following 6 months of biologic therapy were age ( p = 0.001 ), BMI ( p < 0.0001 ), and serum adiponectin levels ( p = 0.027 ).
In conclusion, in nondiabetic patients with moderate-to-severe psoriasis, TBS correlates with metabolic syndrome features and inflammation.
This association is still present after 6 months of adalimumab therapy.
Moreover, serum adiponectin levels seem to be an independent variable related to TBS values, after adalimumab therapy.
American Psychological Association (APA)
Hernández, José L.& López-Mejías, Raquel& Blanco, Ricardo& Pina, Trinitario& Ruiz, Sheila& Sierra, Isabel…[et al.]. 2016. Association of Trabecular Bone Score with Inflammation and Adiposity in Patients with Psoriasis: Effect of Adalimumab Therapy. Journal of Osteoporosis،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1110162
Modern Language Association (MLA)
Hernández, José L.…[et al.]. Association of Trabecular Bone Score with Inflammation and Adiposity in Patients with Psoriasis: Effect of Adalimumab Therapy. Journal of Osteoporosis No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1110162
American Medical Association (AMA)
Hernández, José L.& López-Mejías, Raquel& Blanco, Ricardo& Pina, Trinitario& Ruiz, Sheila& Sierra, Isabel…[et al.]. Association of Trabecular Bone Score with Inflammation and Adiposity in Patients with Psoriasis: Effect of Adalimumab Therapy. Journal of Osteoporosis. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1110162
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110162