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Hypothyroidism in Pancreatic Cancer: Role of Exogenous Thyroid Hormone in Tumor Invasion—Preliminary Observations
المؤلفون المشاركون
Yeo, Charles J.
Chipitsyna, Galina I.
Sarosiek, Konrad
Gandhi, Ankit V.
Saxena, Shivam
Kang, Christopher Y.
Arafat, Hwyda A.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
According to the epidemiological studies, about 4.4% of American general elderly population has a pronounced hypothyroidism and relies on thyroid hormone supplements daily.
The prevalence of hypothyroidism in our patients with pancreatic cancer was much higher, 14.1%.
A retrospective analysis was performed on patients who underwent pancreaticoduodenectomy (Whipple procedure) or distal pancreatectomy and splenectomy (DPS) at Thomas Jefferson University Hospital, Philadelphia, from 2005 to 2012.
The diagnosis of hypothyroidism was correlated with clinicopathologic parameters including tumor stage, grade, and survival.
To further understand how thyroid hormone affects pancreatic cancer behavior, functional studies including wound-induced cell migration, proliferation, and invasion were performed on pancreatic cancer cell lines, MiaPaCa-2 and AsPC-1.
We found that hypothyroid patients taking exogenous thyroid hormone were more than three times likely to have perineural invasion, and about twice as likely to have higher T stage, nodal spread, and overall poorer prognostic stage ( P < 0.05 ).
Pancreatic cancer cell line studies demonstrated that exogenous thyroid hormone treatment increased cell proliferation, migration, and invasion ( P < 0.05 ).
We conclude that exogenous thyroid hormone may contribute to the progression of pancreatic cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sarosiek, Konrad& Gandhi, Ankit V.& Saxena, Shivam& Kang, Christopher Y.& Chipitsyna, Galina I.& Yeo, Charles J.…[et al.]. 2016. Hypothyroidism in Pancreatic Cancer: Role of Exogenous Thyroid Hormone in Tumor Invasion—Preliminary Observations. Journal of Thyroid Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1110874
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sarosiek, Konrad…[et al.]. Hypothyroidism in Pancreatic Cancer: Role of Exogenous Thyroid Hormone in Tumor Invasion—Preliminary Observations. Journal of Thyroid Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1110874
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sarosiek, Konrad& Gandhi, Ankit V.& Saxena, Shivam& Kang, Christopher Y.& Chipitsyna, Galina I.& Yeo, Charles J.…[et al.]. Hypothyroidism in Pancreatic Cancer: Role of Exogenous Thyroid Hormone in Tumor Invasion—Preliminary Observations. Journal of Thyroid Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1110874
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1110874
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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