Hypothyroidism in Pancreatic Cancer: Role of Exogenous Thyroid Hormone in Tumor Invasion—Preliminary Observations
Joint Authors
Yeo, Charles J.
Chipitsyna, Galina I.
Sarosiek, Konrad
Gandhi, Ankit V.
Saxena, Shivam
Kang, Christopher Y.
Arafat, Hwyda A.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
According to the epidemiological studies, about 4.4% of American general elderly population has a pronounced hypothyroidism and relies on thyroid hormone supplements daily.
The prevalence of hypothyroidism in our patients with pancreatic cancer was much higher, 14.1%.
A retrospective analysis was performed on patients who underwent pancreaticoduodenectomy (Whipple procedure) or distal pancreatectomy and splenectomy (DPS) at Thomas Jefferson University Hospital, Philadelphia, from 2005 to 2012.
The diagnosis of hypothyroidism was correlated with clinicopathologic parameters including tumor stage, grade, and survival.
To further understand how thyroid hormone affects pancreatic cancer behavior, functional studies including wound-induced cell migration, proliferation, and invasion were performed on pancreatic cancer cell lines, MiaPaCa-2 and AsPC-1.
We found that hypothyroid patients taking exogenous thyroid hormone were more than three times likely to have perineural invasion, and about twice as likely to have higher T stage, nodal spread, and overall poorer prognostic stage ( P < 0.05 ).
Pancreatic cancer cell line studies demonstrated that exogenous thyroid hormone treatment increased cell proliferation, migration, and invasion ( P < 0.05 ).
We conclude that exogenous thyroid hormone may contribute to the progression of pancreatic cancer.
American Psychological Association (APA)
Sarosiek, Konrad& Gandhi, Ankit V.& Saxena, Shivam& Kang, Christopher Y.& Chipitsyna, Galina I.& Yeo, Charles J.…[et al.]. 2016. Hypothyroidism in Pancreatic Cancer: Role of Exogenous Thyroid Hormone in Tumor Invasion—Preliminary Observations. Journal of Thyroid Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1110874
Modern Language Association (MLA)
Sarosiek, Konrad…[et al.]. Hypothyroidism in Pancreatic Cancer: Role of Exogenous Thyroid Hormone in Tumor Invasion—Preliminary Observations. Journal of Thyroid Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1110874
American Medical Association (AMA)
Sarosiek, Konrad& Gandhi, Ankit V.& Saxena, Shivam& Kang, Christopher Y.& Chipitsyna, Galina I.& Yeo, Charles J.…[et al.]. Hypothyroidism in Pancreatic Cancer: Role of Exogenous Thyroid Hormone in Tumor Invasion—Preliminary Observations. Journal of Thyroid Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1110874
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110874