Significance of Interleukin-6 in Papillary Thyroid Carcinoma
المؤلفون المشاركون
Kobawala, Toral P.
Trivedi, Trupti I.
Gajjar, Kinjal K.
Patel, Darshita H.
Ghosh, Nandita R.
Patel, Girish H.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-13
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
This study sought to reveal the significance of IL-6 in papillary thyroid carcinoma by determining its circulating levels, tumoral protein, and mRNA expressions.
As compared to the healthy individuals, serum IL-6 was significantly higher in patients with benign thyroid diseases and PTC.
Further, its level was significantly higher in PTC patients as compared to patients with benign thyroid diseases.
ROC curves also confirmed a good discriminatory efficacy of serum IL-6 between healthy individuals and patients with benign thyroid diseases and PTC.
The circulating IL-6 was significantly associated with poor overall survival in PTC patients.
IL-6 immunoreactivity was significantly high in PTC patients as compared to the benign thyroid disease patients.
Significantly higher IL-6 mRNA expression was also observed in the primary tumour tissues of PTC patients than the adjacent normal tissues.
The protein expression of IL-6 at both the circulating and tissue level correlated with disease aggressiveness in PTC patients.
Moreover, a significant positive correlation was observed between the IL-6 protein and mRNA expression in the primary tumours of PTC patients.
Finally in conclusion, IL-6 has an important role in thyroid cancer progression.
Thus targeting IL-6 signalling can help in clinical management of thyroid carcinoma patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kobawala, Toral P.& Trivedi, Trupti I.& Gajjar, Kinjal K.& Patel, Darshita H.& Patel, Girish H.& Ghosh, Nandita R.. 2016. Significance of Interleukin-6 in Papillary Thyroid Carcinoma. Journal of Thyroid Research،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1110878
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kobawala, Toral P.…[et al.]. Significance of Interleukin-6 in Papillary Thyroid Carcinoma. Journal of Thyroid Research No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1110878
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kobawala, Toral P.& Trivedi, Trupti I.& Gajjar, Kinjal K.& Patel, Darshita H.& Patel, Girish H.& Ghosh, Nandita R.. Significance of Interleukin-6 in Papillary Thyroid Carcinoma. Journal of Thyroid Research. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1110878
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1110878
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر