Significance of Interleukin-6 in Papillary Thyroid Carcinoma
Joint Authors
Kobawala, Toral P.
Trivedi, Trupti I.
Gajjar, Kinjal K.
Patel, Darshita H.
Ghosh, Nandita R.
Patel, Girish H.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This study sought to reveal the significance of IL-6 in papillary thyroid carcinoma by determining its circulating levels, tumoral protein, and mRNA expressions.
As compared to the healthy individuals, serum IL-6 was significantly higher in patients with benign thyroid diseases and PTC.
Further, its level was significantly higher in PTC patients as compared to patients with benign thyroid diseases.
ROC curves also confirmed a good discriminatory efficacy of serum IL-6 between healthy individuals and patients with benign thyroid diseases and PTC.
The circulating IL-6 was significantly associated with poor overall survival in PTC patients.
IL-6 immunoreactivity was significantly high in PTC patients as compared to the benign thyroid disease patients.
Significantly higher IL-6 mRNA expression was also observed in the primary tumour tissues of PTC patients than the adjacent normal tissues.
The protein expression of IL-6 at both the circulating and tissue level correlated with disease aggressiveness in PTC patients.
Moreover, a significant positive correlation was observed between the IL-6 protein and mRNA expression in the primary tumours of PTC patients.
Finally in conclusion, IL-6 has an important role in thyroid cancer progression.
Thus targeting IL-6 signalling can help in clinical management of thyroid carcinoma patients.
American Psychological Association (APA)
Kobawala, Toral P.& Trivedi, Trupti I.& Gajjar, Kinjal K.& Patel, Darshita H.& Patel, Girish H.& Ghosh, Nandita R.. 2016. Significance of Interleukin-6 in Papillary Thyroid Carcinoma. Journal of Thyroid Research،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1110878
Modern Language Association (MLA)
Kobawala, Toral P.…[et al.]. Significance of Interleukin-6 in Papillary Thyroid Carcinoma. Journal of Thyroid Research No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1110878
American Medical Association (AMA)
Kobawala, Toral P.& Trivedi, Trupti I.& Gajjar, Kinjal K.& Patel, Darshita H.& Patel, Girish H.& Ghosh, Nandita R.. Significance of Interleukin-6 in Papillary Thyroid Carcinoma. Journal of Thyroid Research. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1110878
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110878