Significance of TNF-α and the Adhesion Molecules: L-Selectin and VCAM-1 in Papillary Thyroid Carcinoma
المؤلفون المشاركون
Kobawala, Toral P.
Trivedi, Trupti I.
Gajjar, Kinjal K.
Patel, Darshita H.
Ghosh, Nandita R.
Patel, Girish H.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-11
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Circulating levels of TNF-α and the adhesion molecules L-Selectin and VCAM-1 as well as their expression in the primary tumors of patients with benign thyroid diseases and papillary thyroid carcinoma (PTC) have been determined in this study.
The serum levels of TNF-α, L-Selectin, and VCAM-1 were significantly higher in patients with both benign thyroid diseases and PTC as compared to the healthy individuals.
However, the levels of only TNF-α and L-Selectin, and not VCAM-1, were significantly higher in patients with PTC in comparison to those observed in patients with benign thyroid diseases.
Further the expression of TNF-α and L-Selectin was also significantly higher in the primary tumors of PTC patients, relative to the benign thyroid diseases.
The expression of L-Selectin and VCAM-1 significantly correlated with aggressive tumor behavior.
In PTC patients, the circulating TNF-α levels significantly positively correlated with the levels of L-Selectin, while TNF-α immunoreactivity was significantly associated with VCAM-1 expression.
Serum TNF-α was found to be a significant prognosticator for OS in PTC patients.
Overall the results signify that the interaction between TNF-α and the adhesion molecules may have a role in thyroid carcinogenesis and understanding this complexity may offer potential therapeutic targets for better management of thyroid cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kobawala, Toral P.& Trivedi, Trupti I.& Gajjar, Kinjal K.& Patel, Darshita H.& Patel, Girish H.& Ghosh, Nandita R.. 2016. Significance of TNF-α and the Adhesion Molecules: L-Selectin and VCAM-1 in Papillary Thyroid Carcinoma. Journal of Thyroid Research،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1110881
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kobawala, Toral P.…[et al.]. Significance of TNF-α and the Adhesion Molecules: L-Selectin and VCAM-1 in Papillary Thyroid Carcinoma. Journal of Thyroid Research No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1110881
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kobawala, Toral P.& Trivedi, Trupti I.& Gajjar, Kinjal K.& Patel, Darshita H.& Patel, Girish H.& Ghosh, Nandita R.. Significance of TNF-α and the Adhesion Molecules: L-Selectin and VCAM-1 in Papillary Thyroid Carcinoma. Journal of Thyroid Research. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1110881
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1110881
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر