Significance of TNF-α and the Adhesion Molecules: L-Selectin and VCAM-1 in Papillary Thyroid Carcinoma
Joint Authors
Kobawala, Toral P.
Trivedi, Trupti I.
Gajjar, Kinjal K.
Patel, Darshita H.
Ghosh, Nandita R.
Patel, Girish H.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-11
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Circulating levels of TNF-α and the adhesion molecules L-Selectin and VCAM-1 as well as their expression in the primary tumors of patients with benign thyroid diseases and papillary thyroid carcinoma (PTC) have been determined in this study.
The serum levels of TNF-α, L-Selectin, and VCAM-1 were significantly higher in patients with both benign thyroid diseases and PTC as compared to the healthy individuals.
However, the levels of only TNF-α and L-Selectin, and not VCAM-1, were significantly higher in patients with PTC in comparison to those observed in patients with benign thyroid diseases.
Further the expression of TNF-α and L-Selectin was also significantly higher in the primary tumors of PTC patients, relative to the benign thyroid diseases.
The expression of L-Selectin and VCAM-1 significantly correlated with aggressive tumor behavior.
In PTC patients, the circulating TNF-α levels significantly positively correlated with the levels of L-Selectin, while TNF-α immunoreactivity was significantly associated with VCAM-1 expression.
Serum TNF-α was found to be a significant prognosticator for OS in PTC patients.
Overall the results signify that the interaction between TNF-α and the adhesion molecules may have a role in thyroid carcinogenesis and understanding this complexity may offer potential therapeutic targets for better management of thyroid cancer.
American Psychological Association (APA)
Kobawala, Toral P.& Trivedi, Trupti I.& Gajjar, Kinjal K.& Patel, Darshita H.& Patel, Girish H.& Ghosh, Nandita R.. 2016. Significance of TNF-α and the Adhesion Molecules: L-Selectin and VCAM-1 in Papillary Thyroid Carcinoma. Journal of Thyroid Research،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1110881
Modern Language Association (MLA)
Kobawala, Toral P.…[et al.]. Significance of TNF-α and the Adhesion Molecules: L-Selectin and VCAM-1 in Papillary Thyroid Carcinoma. Journal of Thyroid Research No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1110881
American Medical Association (AMA)
Kobawala, Toral P.& Trivedi, Trupti I.& Gajjar, Kinjal K.& Patel, Darshita H.& Patel, Girish H.& Ghosh, Nandita R.. Significance of TNF-α and the Adhesion Molecules: L-Selectin and VCAM-1 in Papillary Thyroid Carcinoma. Journal of Thyroid Research. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1110881
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110881