Regulation of Autophagy-Related Protein and Cell Differentiation by High Mobility Group Box 1 Protein in Adipocytes
المؤلفون المشاركون
Wang, Hui
Yu, Lili
Yang, Can
Liu, Guoyan
Song, Xiangfeng
Feng, Huanhuan
Zhang, Guojun
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-24
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
High mobility group box 1 protein (HMGB1) is a molecule related to the development of inflammation.
Autophagy is vital to maintain cellular homeostasis and protect against inflammation of adipocyte injury.
Our recent work focused on the relationship of HMGB1 and autophagy in 3T3-L1 cells.
In vivo experimental results showed that, compared with the normal-diet group, the high-fat diet mice displayed an increase in adipocyte size in the epididymal adipose tissues.
The expression levels of HMGB1 and LC3II also increased in epididymal adipose tissues in high-fat diet group compared to the normal-diet mice.
The in vitro results indicated that HMGB1 protein treatment increased LC3II formation in 3T3-L1 preadipocytes in contrast to that in the control group.
Furthermore, LC3II formation was inhibited through HMGB1 knockdown by siRNA.
Treatment with the HMGB1 protein enhanced LC3II expression after 2 and 4 days but decreased the expression after 8 and 10 days among various differentiation stages of adipocytes.
By contrast, FABP4 expression decreased on the fourth day and increased on the eighth day.
Hence, the HMGB1 protein modulated autophagy-related proteins and lipid-metabolism-related genes in adipocytes and could be a new target for treatment of obesity and related metabolic diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Feng, Huanhuan& Yu, Lili& Zhang, Guojun& Liu, Guoyan& Yang, Can& Wang, Hui…[et al.]. 2016. Regulation of Autophagy-Related Protein and Cell Differentiation by High Mobility Group Box 1 Protein in Adipocytes. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1110952
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Feng, Huanhuan…[et al.]. Regulation of Autophagy-Related Protein and Cell Differentiation by High Mobility Group Box 1 Protein in Adipocytes. Mediators of Inflammation No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1110952
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Feng, Huanhuan& Yu, Lili& Zhang, Guojun& Liu, Guoyan& Yang, Can& Wang, Hui…[et al.]. Regulation of Autophagy-Related Protein and Cell Differentiation by High Mobility Group Box 1 Protein in Adipocytes. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1110952
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1110952
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر