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Regulation of Autophagy-Related Protein and Cell Differentiation by High Mobility Group Box 1 Protein in Adipocytes
Joint Authors
Wang, Hui
Yu, Lili
Yang, Can
Liu, Guoyan
Song, Xiangfeng
Feng, Huanhuan
Zhang, Guojun
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
High mobility group box 1 protein (HMGB1) is a molecule related to the development of inflammation.
Autophagy is vital to maintain cellular homeostasis and protect against inflammation of adipocyte injury.
Our recent work focused on the relationship of HMGB1 and autophagy in 3T3-L1 cells.
In vivo experimental results showed that, compared with the normal-diet group, the high-fat diet mice displayed an increase in adipocyte size in the epididymal adipose tissues.
The expression levels of HMGB1 and LC3II also increased in epididymal adipose tissues in high-fat diet group compared to the normal-diet mice.
The in vitro results indicated that HMGB1 protein treatment increased LC3II formation in 3T3-L1 preadipocytes in contrast to that in the control group.
Furthermore, LC3II formation was inhibited through HMGB1 knockdown by siRNA.
Treatment with the HMGB1 protein enhanced LC3II expression after 2 and 4 days but decreased the expression after 8 and 10 days among various differentiation stages of adipocytes.
By contrast, FABP4 expression decreased on the fourth day and increased on the eighth day.
Hence, the HMGB1 protein modulated autophagy-related proteins and lipid-metabolism-related genes in adipocytes and could be a new target for treatment of obesity and related metabolic diseases.
American Psychological Association (APA)
Feng, Huanhuan& Yu, Lili& Zhang, Guojun& Liu, Guoyan& Yang, Can& Wang, Hui…[et al.]. 2016. Regulation of Autophagy-Related Protein and Cell Differentiation by High Mobility Group Box 1 Protein in Adipocytes. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1110952
Modern Language Association (MLA)
Feng, Huanhuan…[et al.]. Regulation of Autophagy-Related Protein and Cell Differentiation by High Mobility Group Box 1 Protein in Adipocytes. Mediators of Inflammation No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1110952
American Medical Association (AMA)
Feng, Huanhuan& Yu, Lili& Zhang, Guojun& Liu, Guoyan& Yang, Can& Wang, Hui…[et al.]. Regulation of Autophagy-Related Protein and Cell Differentiation by High Mobility Group Box 1 Protein in Adipocytes. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1110952
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110952