Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema
المؤلفون المشاركون
Hilty, Matthias Peter
Zügel, Stefanie
Schoeb, Michele
Auinger, Katja
Dehnert, Christoph
Maggiorini, Marco
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-09
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Introduction.
Acute exposure to high altitude induces inflammation.
However, the relationship between inflammation and high altitude related illness such as high altitude pulmonary edema (HAPE) and acute mountain sickness (AMS) is poorly understood.
We tested if soluble urokinase-type plasminogen activator receptor (suPAR) plasma concentration, a prognostic factor for cardiovascular disease and marker for low grade activation of leukocytes, will predict susceptibility to HAPE and AMS.
Methods.
41 healthy mountaineers were examined at sea level (SL, 446 m) and 24 h after rapid ascent to 4559 m (HA).
24/41 subjects had a history of HAPE and were thus considered HAPE-susceptible (HAPE-s).
Out of the latter, 10/24 HAPE-s subjects were randomly chosen to suppress the inflammatory cascade with dexamethasone 8 mg bid 24 h prior to ascent.
Results.
Acute hypoxic exposure led to an acute inflammatory reaction represented by an increase in suPAR ( 1.9 ± 0.4 at SL versus 2.3 ± 0.5 at HA, p < 0.01 ), CRP ( 0.7 ± 0.5 at SL versus 3.6 ± 4.6 at HA, p < 0.01 ), and IL-6 ( 0.8 ± 0.4 at SL versus 3.3 ± 4.9 at HA, p < 0.01 ) in all subjects except those receiving dexamethasone.
The ascent associated decrease in PaO2 correlated with the increase in IL-6 ( r = 0.46 , p < 0.001 ), but not suPAR ( r = 0.27 , p = 0.08 ); the increase in IL-6 was not correlated with suPAR ( r = 0.16 , p = 0.24 ).
Baseline suPAR plasma concentration was higher in the HAPE-s group ( 2.0 ± 0.4 versus 1.8 ± 0.4 , p = 0.04 ); no difference was found for CRP and IL-6 and for subjects developing AMS.
Conclusion.
High altitude exposure leads to an increase in suPAR plasma concentration, with the missing correlation between suPAR and IL-6 suggesting a cytokine independent, leukocyte mediated mechanism of low grade inflammation.
The correlation between IL-6 and PaO2 suggests a direct effect of hypoxia, which is not the case for suPAR.
However, suPAR plasma concentration measured before hypoxic exposure may predict HAPE susceptibility.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hilty, Matthias Peter& Zügel, Stefanie& Schoeb, Michele& Auinger, Katja& Dehnert, Christoph& Maggiorini, Marco. 2016. Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1110955
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hilty, Matthias Peter…[et al.]. Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema. Mediators of Inflammation No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1110955
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hilty, Matthias Peter& Zügel, Stefanie& Schoeb, Michele& Auinger, Katja& Dehnert, Christoph& Maggiorini, Marco. Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1110955
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1110955
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر